Apelin的抗氧化性对氨基糖苷药物所致听力损失保护作用的研究进展  

Research Progress on the Protective Effect of Apelin’s Antioxidant Activity on Aminoglycoside Induced Hearing Loss

作　　者：牛鹏昊 杨欣欣[2] 

机构地区：[1]济宁医学院临床医学院,山东 济宁 [2]济宁医学院附属医院耳鼻咽喉科,山东 济宁

出　　处：《临床个性化医学》2024年第4期2315-2320,共6页Journal of Clinical Personalized Medicine

摘　　要：Apelin是指G蛋白偶联受体APJ中的一种特异性内源性配体,其在体内外均可抑制氧化应激和细胞凋亡。氨基糖苷类抗生素所导致的耳毒性即指氨基糖苷类抗生素所致的机体内耳机构(耳蜗和前庭器官)及其功能(听力和平衡觉)的损害。目前部分研究已经证明apelin对于氧化应激的调节有助于改善氨基糖苷类抗生素所带来的药物耳毒性影响。本文将从Apelin对氧化应激机制的调控和活性氧(ROS)过量堆积是氨基糖苷类抗生素所致的耳毒性的重要原因,以及apelin可以通过抑制氧化应激从而减轻氨基糖苷抗生素所导致的听力损失进行综述,旨在为氨基糖苷类临床药物所致耳毒性的毒副作用寻找科学可行的临床思路及新型防治策略。Apelin refers to a specific endogenous ligand in G protein-coupled receptor APJ that inhibits oxidative stress and apoptosis both in vivo and in vitro. Ototoxicity caused by aminoglycoside antibiotics refers to the impairment of inner ear organs (cochlea and vestibular organs) and their functions (hearing and balance) caused by aminoglycoside antibiotics. Some studies have shown that apelin’s regulation of oxidative stress helps to ameliorate the ototoxic effects of aminoglycoside antibiotics. This article will review the regulation of oxidative stress mechanism by Apelin and the important cause of ototoxicity caused by aminoglycoside antibiotics due to excessive accumulation of reactive oxygen species (ROS), and how apelin can reduce hearing loss caused by aminoglycoside antibiotics by inhibiting oxidative stress. The aim is to find scientific and feasible clinical ideas and new prevention strategies for the side effects of ototoxicity caused by aminoglycoside drugs.

关 键 词：APELIN 氧化应激 氨基糖苷类抗生素 听力损失 耳毒性 

分 类 号：R54[医药卫生—心血管疾病]