3种雷公藤制剂治疗糖尿病肾病的新研究进展  

New Research Progress of Three Tripterygium wilfordii Preparations for the Treatment of Diabetic Nephropathy

作　　者：陈星海 邓云婷 苏炳华 王德重 王涛[2] 

机构地区：[1]黑龙江省中医药科学院,黑龙江 哈尔滨 [2]黑龙江省中医医院,黑龙江 哈尔滨

出　　处：《临床个性化医学》2024年第4期2491-2497,共7页Journal of Clinical Personalized Medicine

基　　金：黑龙江省级领军人才梯队后备带头人基金项目(黑人社涵[2022] 534)。

摘　　要：糖尿病肾病作为糖尿病最严重的并发症之一,是导致终末期肾病的最主要原因,给人们的生命健康造成了极大威胁,然而现代医学对此疾病没有特效的治疗手段。雷公藤多苷片、火把花根片、昆仙胶囊为3种常见的雷公藤制剂,研究发现其对糖尿病肾病有一定的治疗作用,但大多为单方面、单机制的研究,缺乏对整体临床疗效及作用机制的总结与归纳。因此,本文通过检索中国知网(CNKI)、PubMed两大中文与英文数据库近10年来收录的关于此3种雷公藤制剂治疗糖尿病肾病的研究文献,并进行分析与总结归纳,从临床疗效以及作用机制两方面阐述雷公藤制剂治疗糖尿病肾病的研究进展,为临床用药提供依据。As one of the most serious complications of diabetes, diabetic nephropathy is the main cause of end-stage renal disease, which poses a great threat to people’s lives and health, but modern medicine has no specific treatment for this disease. Tripterygium wilfordii polyglycoside tablets, torch flower root tablets, and Kunxian capsules are three common preparations, which have been found to have a certain therapeutic effect on diabetic nephropathy, but most of them are unilateral and single-mechanism studies, and there is a lack of summary and induction of the overall clinical efficacy and mechanism of action. Therefore, this paper retrieved the research literature on the treatment of diabetic nephropathy with these three Tripterygium wilfordii preparations collected in the past 10 years from the two Chinese and English databases of China National Knowledge Infrastructure (CNKI) and PubMed, and analyzed and summarized the research progress of Tripterygium wilfordii preparations in the treatment of diabetic nephropathy from the aspects of clinical efficacy and mechanism of action, so as to provide a basis for clinical use.

关 键 词：雷公藤多苷片 昆仙胶囊 火把花根片 糖尿病肾病 

分 类 号：R28[医药卫生—中药学]