综述:急性肺损伤的不同干细胞治疗研究进展  

Advances in Stem Cell Therapy for Acute Lung Injury: A Review

作　　者：杨阳 李建英 

机构地区：[1]西安市中心医院呼吸与危重症学科,陕西 西安 [2]西安市胸科医院呼吸与危重症医学科,陕西 西安

出　　处：《临床个性化医学》2025年第1期326-333,共8页Journal of Clinical Personalized Medicine

基　　金：陕西省西安市英才计划菁英项目(编号:XAYC210062);陕西省西安市科技计划计划项目(编号:2024YXYJ0004);陕西省西安市科技计划项目(编号:2021ZD04);陕西省西安市科技计划项目(编号:23YXYJ0061)。

摘　　要：急性肺损伤(ALI)是一种具有高发病率和高死亡率的严重疾病,目前缺乏有效的治疗手段。近年来,干细胞治疗因其多能性和再生能力受到广泛关注。本综述总结了不同类型干细胞(如间充质干细胞、上皮祖细胞、内皮祖细胞等)在急性肺损伤中的治疗潜力,重点阐述了其作用机制、实验研究进展以及临床应用的挑战和未来方向。Acute lung injury (ALI) is a severe clinical condition with high morbidity and mortality rates, for which effective treatment options remain elusive. In recent years, stem cell therapy has emerged as a promising approach due to the pluripotency and regenerative capabilities of stem cells. This review explores the therapeutic potential of various stem cell types, including mesenchymal stem cells (MSCs), epithelial progenitor cells, and endothelial progenitor cells, in the context of ALI. It highlights their mechanisms of action, recent advances in experimental studies, and the challenges associated with clinical translation, while providing insights into future research directions.

关 键 词：急性肺损伤(ALI) 间充质干细胞(MSCs) 干细胞治疗 免疫调节 组织修复 外泌体 肺泡–毛细血管屏障 

分 类 号：R73[医药卫生—肿瘤]