自身免疫性甲状腺疾病对胎盘功能的影响机制研究  

Research on the Mechanisms of Autoimmune Thyroid Diseases Affecting Placental Function

作　　者：廖家湖 印国兵[1] 

机构地区：[1]重庆医科大学附属第二医院乳腺甲状腺外科,重庆

出　　处：《临床个性化医学》2025年第1期510-519,共10页Journal of Clinical Personalized Medicine

摘　　要：自身免疫性甲状腺疾病(AITD)是育龄期女性甲状腺功能异常的常见原因。与普通人群相比,AITD患者不孕症患病率更高。AITD与不孕症的相关性涉及甲状腺激素水平失调、甲状腺自身抗体对卵巢组织及生殖系统的损害、免疫系统的异常反应等多个原因,但具体机制尚不明确。本研究旨在通过现有文献,深入探讨AITD对胎盘功能的影响机制,揭示其潜在的生物学路径,并为临床管理提供科学依据。通过对AITD与胎盘功能交互作用的全面分析,期望为改善妊娠结局和提高母婴健康水平提供新的视角和策略。Autoimmune thyroid disease (AITD) is a common cause of thyroid dysfunction in women of childbearing age. Compared with the general population, the prevalence of infertility is higher among patients with AITD. The correlation between AITD and infertility involves multiple factors such as thyroid hormone level disorders, damage to ovarian tissue and the reproductive system caused by thyroid autoantibodies, and abnormal immune responses, but the specific mechanisms are not yet clear. This study aims to explore in depth the mechanisms by which AITD affects placental function through existing literature, reveal its potential biological pathways, and provide a scientific basis for clinical management. Through a comprehensive analysis of the interaction between AITD and placental function, it is hoped to provide new perspectives and strategies for improving pregnancy outcomes and enhancing the health level of mothers and babies.

关 键 词：自身免疫性甲状腺疾病(AITD) 桥本氏甲状腺炎 GRAVES病 胎盘功能 

分 类 号：R58[医药卫生—内分泌]