呫吨酮类化合物的合成及生物活性研究进展  

The Research Progress about Synthesis and Biological Activities of Xanthones

作　　者：郝晓盼 林军[1] 严胜骄[1] 

机构地区：[1]云南大学化学科学与工程学院教育部自然资源药物化学重点实验室,云南昆明

出　　处：《有机化学研究》2015年第3期122-137,共16页Journal of Organic Chemistry Research

基　　金：国家自然科学基金项目(No.21362042,U1202221,21162037,21262042,81160384)资助。

摘　　要：呫吨酮类化合物具有消炎、镇痛、抗病毒、抗肿瘤等广谱的生物活性。通过对呫吨酮骨架结构进行修饰是合成生物活性药物的重要方法。呫吨酮骨架成为合成具有生物活性分子的重要砌块。本文对呫吨酮母体骨架的合成方法及呫吨酮类化合物的活性研究进行了简要介绍。合成方法包括金属催化及生物合成法等,并对近年来国内外对呫吨酮类化合物生物活性的研究进行简单介绍。Xanthones have been found to possess wide biological activities including anti-inflammatory, anal-gesic, antivirus, antitumor etc. It is an important way to synthesize biologically active drugs by modification of the structure of xanthones. The skeleton structure of xanthone has been severed as the building blocks to synthesis of bioactive molecules. In this paper, the synthesis methods and the active research of xanthones were summarized in brief. The synthesis methods included metal catalyzed syntheses, biosynthesis and so on. At the same time, the paper briefly introduces the re-search of biological activity of xanthones, which has been reported at home and abroad for many years.

关 键 词：呫吨酮 合成 生物活性 

分 类 号：R28[医药卫生—中药学]