银促进的α-氨基芳乙酮与NH₄PF₆的缩合环化反应:2-芳甲酰基咪唑衍生物的合成研究  

Silver-Promoted Cyclization of α-Aminoacetophenone with NH4PF6: Synthesis of 2-Arylformylimidazole Derivatives

作　　者：王祚辉 程晓雪 王浩[1] 凌心茹 赵晨晨[1] 胡茂林[1] 

机构地区：[1]温州大学化学与材料工程学院,浙江温州

出　　处：《有机化学研究》2016年第1期6-12,共7页Journal of Organic Chemistry Research

摘　　要：本文发展了一种由六氟磷酸铵提供铵源,与两分子α-氨基芳乙酮在醋酸银的氧化作用下,经过缩合、脱胺、环化等串联反应合成2-芳甲酰基咪唑衍生物的新方法。在最优条件下,合成了8种2-芳甲酰基咪唑衍生物,收率为52%~93%。所有的产物结构通过IR、NMR和MS等手段表征。该方法具有原料简单易得、操作简便等优点。A new method for AgOAc-oxidative cyclization of α-aminoacetophenones with NH4PF6 leading to 2-arylformylimidazoles derivatives has been developed. Under the optimal reaction conditions, a wide range of 2-arylformylimidazoles derivatives were synthesized in moderate to good yields ranging from 52% to 93%. These products were confirmed by IR, NMR and MS. The results show that this method has advantages such as the availability for raw materials and simple chemical operations.

关 键 词：α-氨基芳乙酮 咪唑 缩合反应 环化反应 氧化脱胺 

分 类 号：O62[理学—有机化学]