磷钨酸促进的酰肼与查尔酮缩合反应的研究  

Study on the Condensation Reaction of Hydrazide with Benzylideneacetophenone Catalyzed by Phosphotungstic Acid

作　　者：吴阳[1] 邢雪建 邢刘桩 侯亚东 杨敬辉 惠永海[1] Yang Wu;Xuejian Xing;Liuzhuang Xing;Yadong Hou;Jinghui Yang;Yonghai Hui(College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi Xinjiang)

机构地区：[1]新疆大学化学化工学院,新疆乌鲁木齐

出　　处：《有机化学研究》2016年第4期93-99,共7页Journal of Organic Chemistry Research

基　　金：国家自然科学基金(Nos.21161026,21362036)。

摘　　要：本文以杂多酸–磷钨酸为催化剂,对酰肼与查尔酮的缩合反应进行了研究。经过一系列反应条件的筛选,确立了最佳反应条件,并对底物的普适性进行了考察,得到了一系列高产率的酰腙类目标产物,最高产率达到99%。本反应操作简单,条件温和,为查尔酮酰腙合成提供了一种新的方法。The condensation of hydrazide with benzylideneacetophenone was studied by using phospho-tungstic acid as catalyst. After a series of reaction conditions, the optimal reaction conditions were established, and the universality of the substrate was investigated. A series of acylhydrazones were obtained with the high yields, up to 99%. The reaction was simple and mild, which provided a new method for the synthesis of chalcone hydrazone.

关 键 词：杂多酸 缩合反应 酰腙 

分 类 号：O62[理学—有机化学]