赭曲霉次生代谢产物研究  

Study on the Secondary Metabolites of Aspergillus ochraceus

作　　者：邹琼宇[1] 吴海峰 黄俊 张莉[1] 陈迪钊[1] 李欣[1] 贺贵妃 梁芬芳 

机构地区：[1]湖南省怀化学院,民族药用植物资源研究与利用湖南省重点实验室,化学与化学工程系,湖南怀化 [2]中国医学科学院北京协和医学院,药用植物研究所,中草药物质基础与资源利用教育部重点实验室,北京

出　　处：《有机化学研究》2017年第2期94-99,共6页Journal of Organic Chemistry Research

基　　金：湖南省高校产业化培育项目(项目编号:11CY013);民族药用植物资源研究与利用湖南省重点实验室开放基金项目(项目编号:YYZW2016-11)。

摘　　要：目的:研究赭曲霉次生代谢产物。方法:利用多种色谱层析方法分离出次生代谢产物,通过ESI-MS/MS及NMR等波谱方法鉴定结构。结果:共分离鉴定出9种化合物,依次是赭曲霉毒素A(1)、赭曲霉毒素B(2)、neohydroxyaspergillic acid(3)、(3R)-5-hydroxymellein(4)、5,6-dihydropenicillic acid(5)、mesaconic acid(6)、p-hydroxybenzoic acid(7)、circumdatin G(8)、(22E,24R)-ergosta-7,22-diene-3β,5α,6β- triol(9)。结论:化合物3~9为首次从赭曲霉中分离得到的化合物。Objective: To study the secondary metabolites from Aspergillus ochraceus. Methods: The constit-uents were isolated and purified by column chromatography and preparative TLC. Their structures were identified on the basis of comprehensive spectroscopic methods including ESI-MS and spectral data (1H, 13C-NMR). Results: Nine compounds were isolated and identified as ochratoxin A (1), ochratoxin B (2), neohydroxyaspergillic acid (3), (3R)-5-hydroxymellein (4), 5,6-dihydro- penicillic acid (5), mesaconic acid (6), p-hydroxybenzoic acid (7), circumdatin G (8), (22E,24R)- ergosta-7,22-diene-3β,5α,6β-triol (9). Conclusion: The compounds 3~9 were isolated from Asper-gillus ochraceus for the first time.

关 键 词：赭曲霉 赭曲霉毒素 分离鉴定 

分 类 号：R28[医药卫生—中药学]