固载化FeCl₃催化合成螺环苯并吡喃[2,3-b]吲哚类衍生物  

Synthesis of Spirooxindole-Chromeno[2,3-b]Indole Derivatives Promoted by Immobilized Solid Lewis Acid Catalyst FeCl3

作　　者：刘雪松 于顺明 

机构地区：[1]上海庚彩新材料科技有限公司,鞍山七彩化学股份有限公司上海研发中心,上海

出　　处：《有机化学研究》2020年第2期15-23,共9页Journal of Organic Chemistry Research

摘　　要：高分子固载Lewis酸催化剂相比传统Lewis酸催化剂,在基本保留其原有催化活性、反应条件更温和等特点的同时,还具有对设备低腐蚀性、易于实现连续化、环境友好等显著优点,因而在医药化工领域具有十分广阔的产业化应用前景。本文利用一种固载FeCl3催化剂,即将FeCl3与聚苯乙烯反应制成负载型氯化铁催化剂(PS-FeCl3),催化靛红、苯酚以及2-卤代吲哚化合物的多组分串联环化反应“一锅法”高效合成螺环苯并吡喃[2,3-b]吲哚类衍生物。Polymer-supported Lewis acid catalysts is dominion over traditional ones in a number of aspects for instance;it retains its original catalytic activity, mild reaction conditions are required, which integrate remarkable advantages in catalyst regeneration, low corrosiveness of equipment, easy achievement of continuous production, environment-friendly aspects, etc. since there are great prospects of wide range of applications in the pharmaceutical and fine chemical industry. In this work, an immobilized solid Lewis acid catalyst (PS-FeCl3) was prepared, which catalyzed the multi-component reaction casecade of isatin, phenol and 2-haloindole in one-pot manner to provide diverse spirooxindole-chromeno[2,3-b]indole derivatives with high efficiency.

关 键 词：路易斯酸 固载催化剂 三氯化铁 螺环苯并吡喃[2 3-b]吲哚 多组分串联反应 

分 类 号：O62[理学—有机化学]