Bronsted酸催化串联反应一锅制备3-氨基-1-茚酮  

Bronsted Acid-Catalyzed One-Pot Synthesis of 3-Aminoindan-1-Ones through a Domino Reaction

作　　者：翟伍超 刘家璇 闫佳玉 杜美烨 吕新 康红兰[1] 

机构地区：[1]浙江师范大学化学与生命科学学院,先进催化材料教育部重点实验室,浙江 金华

出　　处：《有机化学研究》2022年第2期39-49,共11页Journal of Organic Chemistry Research

摘　　要：本文主要研究了在有机Bronsted酸催化条件下,由邻乙炔基苯甲醛与环状脂肪仲胺经烯胺化/环化/水解串联反应一锅合成3-氨基-1-茚酮类化合物。该方法具有原料易得、底物适用范围广(各种取代的邻乙炔苯甲醛和环状仲胺均可顺利参与)、产率高(81%~97%)、时间较短(5~9 h)、可放大量制备(20 mmol规模)、一锅合成方式操作便捷等优势。The paper demonstrates the one-pot synthesis of 3-aminoindan-1-ones through the domino enamidation/cyclization/hydrolysis reactions between o-ethynylbenzaldehydes and cyclic aliphatic amines under organic Bronsted acid catalysis. This method possesses many merits, such as the readily available starting materials, broad substrate scope (various substituted o-ethynylbenzaldehydes and cyclic aliphatic amines participated in the reaction successfully), high yields (81%~97%), short reaction time (5~9 h), scalability (20 mmol scale), and convenient one-pot synthetic procedures.

关 键 词：3-氨基-1-茚酮 酸催化 串联反应 邻炔基苯甲醛 一锅合成 

分 类 号：TQ460.1[化学工程—制药化工]