杂环类白藜芦醇衍生物的合成及其药理作用研究综述  

Synthesis and Pharmacological Action of Heterocyclic Resveratrol Derivatives: A Review

作　　者：唐宗军 刘海平 马文晋 

机构地区：[1]兰州交通大学化学化工学院,甘肃 兰州

出　　处：《有机化学研究》2022年第2期69-77,共9页Journal of Organic Chemistry Research

摘　　要：白藜芦醇是众所周知的一种天然非黄酮类化合物,存在于多种植物中,并且具有丰富的药理作用。近年来,受到了广大研究人员广泛的研究。尤其是以白藜芦醇为基本骨架的衍生物,通过对其酚羟基,苯环,双键不同结构的修饰,进而研究其不同药理作用的变化。含有氮、氧、硫等杂原子的杂环具有特殊的药理性质,杂环化合物种类繁多,在自然界中分布广泛。因此,本文主要综述了恶唑、呋喃、噻吩、吡咯、咪唑等杂环对白藜芦醇不同位置修饰的衍生物的合成及药理作用的研究。Resveratrol is a well-known natural non flavonoid compound, which exists in a variety of plants and has rich pharmacological effects. In recent years, it has been widely studied by the majority of researchers. Especially for the derivatives with resveratrol as the basic skeleton, through the modification of different structures of phenolic hydroxyl, benzene ring and double bond, we can study the changes of their different pharmacological effects. Heterocycles containing heteroatoms such as nitrogen, oxygen and sulfur have special pharmacological properties. There are many kinds of heterocyclic compounds, which are widely distributed in nature. Therefore, this paper mainly reviews the synthesis and pharmacological effects of heterocycles such as oxazole, furan, thiophene, pyrrole and imidazole on resveratrol derivatives modified at different positions.

关 键 词：杂环 白藜芦醇 合成 活性 

分 类 号：TQ28[化学工程—有机化工]