4,6-二甲基-4-壬烯-3-酮的合成  

Synthesis of 4,6-Dimethyl-4-nonen-3-one

作　　者：侯忠林 胥秀英[1] 丁锐[1] 郑一敏[1] 赵莎 李游 

机构地区：[1]重庆理工大学,重庆

出　　处：《有机化学研究》2022年第3期90-95,共6页Journal of Organic Chemistry Research

摘　　要：通过3-戊酮和2-甲基戊醛的羟醛缩合反应,建立了4,6-二甲基-4-壬烯-3-酮的高效合成方法。通过单因素实验考察了反应物配比、催化剂用量、反应时间、溶剂用量和反应温度对产率的影响,结果表明,最佳工艺条件为:n (3-戊酮):n (2-甲基戊醛):n (NaOH) = 5:1:0.5,反应时间1.5 h,反应温度75℃,目标产物的产率为92.35%,HPLC质量分数为99.6%。本工艺具有步骤简洁、反应条件温和、反应时间短、收率高、成本低和污染少的优点,适合工业化生产。An efficient synthesis method of 4,6-dimethyl-4-nonene-3-ketone was established by a hydroxyl aldehyde condensation reaction of 3-pentenone and 2-methylpentaldehyde. Through the single factor experiment, factors influencing the product yield are discussed: such as molratio of raw material, amount of catalyst , reaction time, amount of solvent and reaction temperature. The better conditions for this reaction have been established: n (3-pentanone): n (2-methylpentanal): n (NaOH) = 5:1:0.5, the reaction time is 1.5 h, the reaction temperature is 75˚C, and the yield of the target product is 92.35%, and the HPLC mass fraction was 99.6%. The process has the advantages of simple steps, mild reaction conditions, short reaction time, high yield, low cost and less pollution, and it is suitable for industrial production.

关 键 词：3-戊酮 2-甲基戊醛 4 6-二甲基-4-壬烯-3-酮 合成 

分 类 号：O626[理学—有机化学]