β,γ-不饱和-α-酮酸酯在有机合成中的应用研究进展  

Research Progress in the Organic Synthesis of β,γ-Unsaturated-α-Ketoesters

作　　者：孔祥南 郑玥 张虎虎 

机构地区：[1]兰州交通大学化学化工学院,甘肃 兰州

出　　处：《有机化学研究》2024年第2期306-317,共12页Journal of Organic Chemistry Research

摘　　要：β,γ-不饱和-α-酮酸酯是一类具有特殊共轭结构的有机中间体,其在有机合成中可以充当C1、C2、C3和C4合成子,可以用于合成具有手性结构或者非手性结构的化合物,因此,β,γ-不饱和-α-酮酸酯已成为现代有机合成中极具吸引力且用途广泛的合成子。本文重点介绍了β,γ-不饱和-α-酮酸酯作为不同合成子在有机合成中的应用,如不对称1,4-加成反应、[2 + 3]环加成反应、[3 + 2]环加成反应以及构建螺环化合物和六元杂环化合物的应用。β,γ-Unsaturated-α-ketoesters are a class of organic intermediates with a unique conjugated structure, which can serve as C1, C2, C3, and C4 synthons in organic synthesis, and can be used to synthesize compounds with chiral or non-chiral structures. Therefore, β,γ-unsaturated-α-ketoesters have become highly attractive and versatile building blocks in modern organic chemistry. This review focuses on introducing β,γ-Unsaturation-α- the application of ketone esters as different synthons in organic synthesis, such as asymmetric 1,4-addition reactions, [2 + 3] cycloaddition reactions, [3 + 2] cycloaddition reactions, as well as the construction of spirocyclic compounds and hexagonal heterocyclic compounds.

关 键 词：β γ-不饱和-α-酮酸酯 合成子 有机中间体 

分 类 号：O62[理学—有机化学]