铁棒锤中的二萜生物碱  

Diterpenoid Alkaloids from Aconitum pendulum Busch

作　　者：何少军 许纪龙 余祥浪 

机构地区：[1]兰州交通大学化学化工学院,甘肃 兰州

出　　处：《有机化学研究》2024年第2期353-358,共6页Journal of Organic Chemistry Research

摘　　要：目的:研究铁棒锤Aconitum pendulum Busch的化学成分。方法:铁棒锤提取物采用大孔树脂,硅胶柱层析以及半制备高效液相色谱对其进行分离纯化,根据其波谱数据进行结构解析。结果:从其中分离得到10个化合物,分别鉴定为Songorine (1)、15-acetylsongorine (2)、12-epi-lucidusculine (3)、14-O-acetylneoline (4)、benzoylaconitine (5)、aconitine (6)、3-deoxyaconitine (7)、mesaconitine (8)、10-aconifine (9)、flavaconitine (10)。Objective: This study aims to analyze the chemical composition of Aconitum pendulum Busch. Methods: The extracts obtained from Aconitum pendulum Busch were purified using macroporous resin, silica gel column chromatography, and semi-preparative high-performance liquid chromatography. The structural analyses were conducted based on their spectral data. Results: Ten compounds were isolated from them and identified as Songorine (1), 15-acetylsongorine (2), 12-epi-lucidusculine (3), 14-O-acetylneoline (4), benzoylaconitine (5), aconitine (6), 3-deoxyaconitine (7), mesaconitine (8), 10-aconifine (9), flavaconitine (10).

关 键 词：铁棒锤 二萜生物碱 化学成分 乌头属 

分 类 号：R28[医药卫生—中药学]