钯催化构建C-P键反应的研究进展  

Research Progress in Palladium Catalyzed C-P Bond Construction Reaction

作　　者：姬鸿森 姚龙 吴新星 

机构地区：[1]南通大学,化学化工学院,江苏 南通 [2]南通大学,南通大学分析测试中心,江苏 南通

出　　处：《有机化学研究》2024年第3期446-458,共13页Journal of Organic Chemistry Research

摘　　要：有机磷化合物因其在药物化学、材料化学和有机化学领域的广泛应用,以及作为配体和有机催化剂在有机合成中的显著地位而受到越来越多的关注。通过钯催化构建C-P键的反应,可以将简单底物转化为结构复杂的有机磷化合物,实现具有重要化学价值的化学转化。根据构建的C-P键类型不同,本文对近年来基于过渡金属钯催化的反应策略合成有机磷化合物的反应及关键反应机理进行了综述和探讨,并展望该研究领域的未来发展前景。Organic phosphorus compounds have received increasing attention due to their widespread applications in pharmaceutical chemistry, material chemistry, and organic chemistry, as well as their outstanding position as ligands and organic catalysts in organic synthesis. The palladium catalyzed C-P bond construction reaction can convert simple substrates into structurally complex organic phosphorus compounds, achieving chemical transformations with significant chemical value. According to the different types of reactions, the synthesis of organophosphorus compounds base on palladium-catalyzed reaction strategies in recent years and the key reaction mechanisms were reviewed and discussed, and the future development prospect of this research field was prospected.

关 键 词：钯催化 有机磷化合物 C-P键 有机合成 

分 类 号：O62[理学—有机化学]