通过重排实现羰基化合物α-芳基化研究进展  

Research Progress in the α-Arylation of Carbonyl Compounds by Rearrangement

作　　者：张理明 

机构地区：[1]浙江师范大学化学与材料科学学院,浙江 金华

出　　处：《有机化学研究》2024年第4期505-512,共8页Journal of Organic Chemistry Research

摘　　要：羰基化合物的α-芳基化是有机合成中非常重要的一类反应,在制药行业受到广泛关注。该类化合物的常规合成方法具有一定的局限性,例如使用化学计量的有毒试剂和苛刻的反应条件。另外,金属催化的羰基化合物的α-芳基化也得到了很大的发展。但反应过程中,需要使用价格昂贵的金属试剂。通过重排反应,也能实现羰基化合物的α-芳基化。反应不涉及有毒试剂和金属催化剂的使用,且底物适用范围广泛,反应条件温和。本文综述了重排反应在这一领域的最新进展。重点介绍了芳基高价碘,芳基四价硫,芳胺参与的[3,3]重排和磺酰胺参与的迁移重排在羰基化合物的α-芳基化方面的研究进展。The α-arylation of carbonyl compounds is a very important reaction in organic synthesis, which has received wide attention in the pharmaceutical industry. The conventional synthesis methods of these compounds have some limitations, such as the use of stoichiometric toxic reagents and harsh reaction conditions. In addition, the metal-catalyzed α-arylation of carbonyl compounds has also been greatly developed. However, expensive metal reagents are needed in the reaction process. The rearrangement reaction can also realize the alpha-arylation of the carbonyl compound. The reaction does not involve the use of toxic reagents and metal catalysts, and has wide application range of substrates and mild reaction conditions. In this paper, the recent progress of rearrangement reactions in this field is reviewed. In this paper, the research progress of α-arylation of carbonyl compounds by [3,3] rearrangement involving aryl hypervalent iodine, aryl tetravalent sulfur, aromatic amine and migration rearrangement involving sulfonamide is emphatically introduced.

关 键 词：羰基化合物 芳基化 重排反应 

分 类 号：O62[理学—有机化学]