金鸡纳生物碱衍生的手性相转移催化剂的研究进展  

Advances in Cinchona Alkaloids as Chiral Phase-Transfer Catalysts

作　　者：李玉 

机构地区：[1]兰州交通大学化学化工学院,甘肃 兰州

出　　处：《有机化学研究》2025年第1期35-46,共12页Journal of Organic Chemistry Research

摘　　要：金鸡纳生物碱因其独特的化学结构和廉价的商业可得性使其在不对称合成中具有许多应用,可以作为有效的有机催化剂或手性配体。不对称相转移催化已成为一个获得手性化合物的重要途径,利用有机小分子催化的不对称合成反应在过去三十多年时间里得到了快速的发展;其中,金鸡纳生物碱衍生的手性相转移催化剂在不对称相转移催化反应中的应用逐渐广泛,且取得了较为理想的效果。各种金鸡纳生物碱衍生的手性相转移催化剂被开发出来,并都表现出了优秀的催化活性和立体选择性。The unique chemical structure and cheap commercial availability of cinchona alkaloids have given them many applications in asymmetric synthesis as effective organocatalysts or chiral ligands. Asymmetric phase transfer catalysis has become an important route to obtain chiral compounds, and asymmetric synthesis reactions catalyzed by organic small molecules have been developed rapidly in the past three decades;among them, chiral phase transfer catalysts derived from chichenna alkaloids have been widely used in asymmetric phase transfer catalyzed reactions, and they have achieved relatively satisfactory results. Various chiral phase transfer catalysts derived from cinchona alkaloids have been developed and all of them have shown excellent catalytic activity and stereoselectivity.

关 键 词：金鸡纳生物碱 不对称相转移催化 有机合成 

分 类 号：O643.3[理学—物理化学]