茚满酮类化合物合成的研究进展  

Research Progress on the Synthesis of Indanone Derivatives

作　　者：江博 

机构地区：[1]兰州交通大学化学化工学院,甘肃 兰州

出　　处：《有机化学研究》2025年第1期47-59,共13页Journal of Organic Chemistry Research

摘　　要：茚满酮是一种含五元环与苯环稠合的有机化合物,茚满酮及其衍生物在医药、农业及有机光电学领域具有显著应用潜力。其合成方法多样,包括经典的Friedel-Crafts反应、金属催化反应和光化学反应等。特别是Nazarov反应,通过α,β-不饱和酮底物的催化环化构建茚满酮骨架。此外,C-H活化反应和光激发反应为合成复杂衍生物提供了新途径。本文总结了近年来茚满酮的主要合成策略,重点探讨了通过六元环和五元环构建骨架的方法,为优化设计合成茚满酮类化合物的路线提供思路。Indanone is an organic compound containing a fused five-membered ring and a benzene ring. indanone and its derivatives have significant potential for application in the fields of medicine, agriculture, and organic optoelectronics. The synthesis methods of indanone derivatives are diverse, including classical Friedel-Crafts reactions, metal-catalyzed reactions, and photochemical reactions. In particular, the Nazarov reaction, which involves the catalytic cyclization of α,β-unsaturated ketone substrates, is commonly used to construct the indanone skeleton. Additionally, C-H activation reactions and photochemical reactions provide new pathways for synthesizing complex derivatives. This paper summarizes the main synthetic strategies for indanone in recent years, with a focus on methods for constructing the skeleton through six-membered and five-membered rings, offering insights for optimizing the design of synthesis routes for indanone derivatives.

关 键 词：茚满酮 环化反应 合成方法 有机小分子 

分 类 号：O621.3[理学—有机化学] O626[理学—化学]