LC3B在心力衰竭中的研究进展  

Research Progress of LC3B in Heart Failure

作　　者：张琪琪 崔英华[2] 

机构地区：[1]济宁医学院临床医学院,山东 济宁 [2]济宁医学院附属医院CCU,山东 济宁

出　　处：《医学诊断》2024年第2期221-226,共6页Medical Diagnosis

摘　　要：心力衰竭是各种心血管疾病的终末阶段,亦是医学界尚未攻克的最后堡垒,给患者、家庭、社会带来沉重负担。LC3B属于LC3/GABARAP蛋白家族,通过介导自噬底物的招募、自噬体的运动、自噬基因的转录,参与自噬调节,保护细胞应对饥饿、缺血、缺氧,抗线粒体氧化应激,在心肌梗死、心肌病、心肌肥大中有重要作用。本综述对LC3B的生物学特点、功能及其通过调节自噬改善心力衰竭进行综述,并为心力衰竭的治疗提供新思路。Heart failure is the final stage of all kinds of cardiovascular diseases, and it is also the last bastion that has not yet been conquered by the medical profession, which has brought a heavy burden to the patients, their families and the society. LC3B belongs to the LC3/GABARAP family of proteins and is involved in the regulation of autophagy by mediating the recruitment of autophagic substrates, autophagosome motility, and transcription of autophagy genes, which protects the cells against starvation, ischemia, and hypoxia, and is resistant to mitochondrial oxidative stress, and has an important role in myocardial infarction, cardiomyopathy, and myocardial hypertrophy. This review provides an overview of the biological characteristics and functions of LC3B and its ability to ameliorate heart failure by regulating autophagy, and provides new ideas for the treatment of heart failure.

关 键 词：心力衰竭 自噬 自噬体 微管相关蛋白1轻链3β 

分 类 号：R54[医药卫生—心血管疾病]