超声二维剪切波弹性成像评估HIV感染者肝纤维化状况的临床研究  

Clinical Study on the Evaluation of Liver Fibrosis in HIV-Infected Patients Using Ultrasonic Two-Dimensional Shear Wave Elastography

作　　者：刘娟[1] 卢海燕 左娟 顾青青 候胜旗 

机构地区：[1]南京医科大学康达学院附属医院连云港第四人民医院超声科,江苏 连云港 [2]台州恩泽医疗中心(集团)超声科,浙江 台州 [3]南京医科大学康达学院附属医院连云港第四人民医院艾滋病门诊,江苏 连云港

出　　处：《医学诊断》2025年第1期1-9,共9页Medical Diagnosis

基　　金：南京医科大学康达学院科研发展基金(项目编号:KD2023KYJJ131);连云港市卫生科技项目(项目编号:ZD202307)。

摘　　要：目的:探讨二维剪切波弹性成像(2D-SWE)在HIV感染者肝纤维化评估中的临床应用价值。方法:前瞻性选取2023年10月~2024年10月157例在本院艾滋病门诊接受正规治疗的HIV感染者和70例年龄、性别相匹配的同期健康正常人作为研究对象。均进行2D-SWE检查及血常规、肝功能等相应的血清学检查,对两组之间所有测量参数进行差异性、相关性的统计学分析。结果:1) 长、短病程组的骨密度按照对照组、短病程组、长病程组的顺序逐渐降低(F = 25.161, P P P Objective: To investigate the clinical value of two-dimensional shear wave elastography (2D-SWE) in the evaluation of liver fibrosis in HIV-Infected patients. Methods: From October 2023 to October 2024, 157 HIV-Infected patients who received formal treatment in the AIDS clinic of our hospital and 70 age and gender-matched healthy people in the same period were prospectively selected as the research objects. 2D-SWE examination, blood routine, liver function, and other corresponding serological tests were performed on all patients. The differences and correlations of all measured parameters between the two groups were statistically analyzed. Results: 1) The BMD of the long and short course groups gradually decreased in the order of the control group, the short course group, and the long course group (F = 25.161, P P P < 0.05). 4) The repeatability test showed good operability and repeatability. 5) Pearson correlation analysis showed that Young’s modulus was positively correlated with the course of disease, ALT, AST, APRI, urine creatinine, triglyceride, and BMI. 6) ROC curve analysis showed that the area under the curve, sensitivity, and specificity of Young’s modulus value were higher than those of APRI and FIB-4. Conclusions: 2D-SWE can quantitatively assess liver fibrosis in HIV-Infected patients at an early stage. Compared with APRI and FIB-4, 2D-SWE can detect changes in liver fibrosis earlier and provide an objective reference for clinical pr

关 键 词：二维剪切波弹性成像 杨氏模量值 肝纤维化 实验室检查 

分 类 号：R51[医药卫生—内科学]