面向射频组织焊接的可降解电极结构设计与实验研究  

Innovative Design and Experimental Study of Degradable Radiofrequency Energy Tissue Welding Electrodes

作　　者：宗乃馨 胡钟欣 邢绪坡 沈俊杰 李俊贤 陈健 宋成利[1] 毛琳 

机构地区：[1]上海理工大学健康科学与工程学院,现代微创医疗器械及技术教育部工程研究中心,上海

出　　处：《建模与仿真》2022年第2期454-464,共11页Modeling and Simulation

摘　　要：目的:研究可降解镁合金作为射频能量组织焊接电极时对肠道吻合口热损伤与生物力学强度的影响。方法:对传统铜电极和新型镁合金电极在射频焊接过程中肠道吻合口的温度变化和组织热损伤进行仿真分析。同时,通过离体实验对仿真结果进行验证,探索在两组电极边缘处和距边缘3 mm处组织温度的变化规律,并对镁合金电极焊接的组织吻合口进行生物力学强度测试和组织微观结构观察。结果:与铜电极相比,镁合金电极能够有效降低焊接区域的平均温度(90℃ vs 75℃)和侧向热损伤距离(3.3 mm vs 2.7 mm),提高吻合口的生物力学强度(爆破压:126.01 ±16.02 mmHg vs 167.01 ±30.41 mmHg,撕脱力:18.87 ±3.15 N vs 22.14 ±1.59 N)。结论:本文验证了镁合金作为射频组织焊接电极的可行性与有效性,所取得的研究成果,为实现人体管腔组织的无缝连接提供了新的思路。Objective: The effect of degradable magnesium alloy as radiofrequency energy tissue welding electrode on thermal damage and biomechanical properties of intestinal anastomosis was studied. Methods: The temperature change and tissue thermal damage of intestinal anastomosis during radiofrequency welding of traditional copper electrode and new magnesium alloy electrode were simulated and analyzed. Meanwhile, the simulation results were verified by in vitro experiments, and the two groups of electrodes were explored at the edge and 3 mm from the edge. The biomechanical properties and microstructure of the anastomosis of magnesium alloy electrode welding were tested. Results: Compared with copper electrode, magnesium alloy electrode can effectively reduce the average temperature of welding zone (90˚C vs 75˚C) and lateral thermal damage distance (3.3 mm vs 2.7 mm), and improve the biomechanical properties of anastomosis (burst pressure: 126.01 ±16.02 mmHg vs 167.01 ±30.41 mmHg, avulsion force: 18.87 ±3.15 N vs 22.14 ±1.59 N). Conclusion: In this study, the feasibility and effectiveness of magnesium alloy as radiofrequency tissue welding electrode were verified, and the research results provided a new idea for realizing the seamless connection of human lumen tissue.

关 键 词：射频组织焊接 镁合金 可降解电极 热损伤 吻合口生物力学强度 

分 类 号：TG1[金属学及工艺—金属学]