基于主客体作用的超分子聚肽纳米药物构建及其性能研究  

Construction and Property Research of Supramolecular Polypeptide Nanomedicine Based on Host-Guest Interactions

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作  者:丁月 马宇轩 朱吕明 姚勇 

机构地区:[1]南通大学化学化工学院,江苏 南通

出  处:《纳米技术》2022年第3期97-104,共8页Hans Journal of Nanotechnology

摘  要:吲哚菁绿(ICG)作为一种具有近红外光敏剂,被广泛应用于癌症的光热治疗。但是,由于ICG的水溶性较差,限制了其在临床上的应用。因此,我们设计并制备了末端修饰了吡啶盐的聚半胱氨酸(PPC),其与水溶性柱[5]芳烃(WP[5])通过主客体识别作用,形成两亲性超分子聚肽。该超分子聚肽通过自组装负载ICG于内核中,形成超分子聚肽纳米药物(WPPC/ICG)。WPPC/ICG通过增强渗透与滞留(EPR)效应靶向富集在肿瘤组织部位,并经内吞作用进入肿瘤细胞后,在细胞内的酸性环境中,响应性地释放出ICG,在808 nm近红外光照射下,局部温度升高,杀死肿瘤细胞,不仅提高了疗效,而且减小了对正常组织的损伤。Indocyanine green (ICG) is widely used as a photosensitizer with near infrared for photothermal therapy. However, the poor water solubility of ICG limits its clinical ap-plication. Therefore, we designed and prepared polycysteine (PPC) with pyridine-terminal modifi-cation, and then formed amphiphilic supramolecular polypeptide with water-soluble pillar[5]arene based on host-guest recognition. The supramolecular polypeptide nanodrug (WPPC/ICG) was then prepared by loading ICG in the core of supramolecular polypeptide nanoassembly. WPPC/ICG could passively target and enrich in tumor tissues via enhanced osmosis and retention (EPR) effect. After entering tumor cells through endocytosis, under acidic intracellular environment, ICG could be re-sponsively released. Under 808 nm near-infrared light, the produced optothermal effect could kill tumor cells, which not only enhanced the therapeutic effect, but also reduced the damage to normal tissue.

关 键 词:吲哚菁绿 光热治疗 主客体作用 超分子纳米药物 

分 类 号:TB383[一般工业技术—材料科学与工程]

 

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