FGF21对慢性–急性酒精性肝损伤的保护作用  

The Protection of FGF21 on Chronic-Binge Alcohol-Induced Liver Injury

作　　者：许韵宇 左伟 谢龙腾 邱国仕 蒋永生 艾为明[1] 林虹[1] 刘彦隆[1] Yunyu Xu;Wei Zuo;Longteng Xie;Guoshi Qiu;Yongsheng Jiang;Weiming Ai;Hong Lin;Yanlong Liu(Wenzhou Medical University,Wenzhou Zhejiang;Ningbo Fourth Hospital,Xiangshan Zhejiang)

机构地区：[1]温州医科大学,浙江温州 [2]宁波市第四医院,浙江象山

出　　处：《自然科学》2016年第4期447-451,共5页Open Journal of Nature Science

基　　金：浙江省新苗人才计划项目(2015R413028);温州市公益性科技计划项目(Y20140739,Y20150094);浙江省医药卫生科技计划(2016KYA166,2016KYB275,2015KYB234);宁波市自然科学基金(2016A610016)。

摘　　要：本文探讨成纤维细胞生长因子21(FGF21)对慢性–急性酒精性肝损伤的保护作用。酒精处理组用慢性–急性酒精处理诱导小鼠肝损伤模型,FGF21保护组在喂酒精饮食的同时每天注射FGF21 (1 mg/kg)。12天后检测各组小鼠肝脏甘油三脂的含量以及外周血中ALT,AST,甘油三脂,游离脂肪酸和甘油的含量。结果发现FGF21可以显著抑制酒精诱导的肝脏脂肪堆积和肝损伤。表明FGF21对慢–急性酒精诱导的肝脏损伤有保护作用。The aim is to investigate the role of FGF21 on chronic-binge alcohol-induced liver injury. Alcohol treatment group was made by chronic-binge alcohol treatment on mice and FGF21 treatment group was made by above alcohol treatment and FGF21 (1 mg/kg) injection daily. Liver triglyceride and plasma ALT, AST, triglyceride, FFA and glycerol were measured 12 days later. Results showed that FGF21 significantly inhibited alcohol-induced fat accumulation and liver injury, which indicated that FGF21 played a protection role on chronic-binge alcohol-induced liver injury.

关 键 词：酒精肝 成纤维细胞生长因子21 

分 类 号：R5[医药卫生—内科学]