LC-MS在手性农药对映体分析中的应用  

Application of LC-MS in Pesticide Enantiomer Analysis

作　　者：王楠 刘宇辉 梁啸[1] 

机构地区：[1]辽宁大学药学院,辽宁 沈阳

出　　处：《自然科学》2024年第3期519-523,共5页Open Journal of Nature Science

摘　　要：目前使用的农药中,手性农药占40%。手性农药具有一个或多个手性中心,同时也具有多对对映异构体,它们在生物活性、生态毒性和环境行为等方面表现出对映选择性差异。利用液相色谱–质谱联用技术(LC-MS)可以分析出如活性高、毒性低的优势对映异构体,推动农药单体的生产和推广,对食品和环境安全具有重要意义。本文综述了LC-MS在手性农药杀菌剂、杀虫剂和除草剂对应异构体分析中的应用,旨在为农药单体使用提供依据。Chiral pesticides account for 40% of the pesticides currently in use. Chiral pesticides have one or more chiral centers as well as multiple pairs of enantiomers, which exhibit enantioselective differences in biological activity, ecotoxicity and environmental behavior. Using liquid chromatography-mass spectrometry (LC-MS), advantageous enantiomers, such as those with high activity and low toxicity, can be analyzed to promote the production and dissemination of pesticide monomers, which is of great significance for food and environmental safety. This paper reviews the application of LC-MS in the analysis of enantiomers corresponding to chiral pesticide fungicides, insecticides and herbicides, aiming to provide a basis for the use of pesticide monomers.

关 键 词：LC-MS 手性农药 对映体 

分 类 号：S48[农业科学—农药学]