浅议AUC/MIC (AUIC)的定义和单位  

Discussion on the Definition and Unit of AUC/MIC (AUIC)

作　　者：俞岚[1] 周洁[2] 高鸿慈 Lan Yu;Jie Zhou;Hongci Gao(Hubei University of Education,Wuhan Hubei;People’s Hospital of Wuhan University,Wuhan Hubei;College of Pharmacy,Hubei University of Chinese Medicine,Wuhan Hubei)

机构地区：[1]湖北第二师范学院,湖北武汉 [2]武汉大学人民医院,湖北武汉 [3]湖北中医药大学药学院,湖北武汉

出　　处：《药物资讯》2017年第1期12-16,共5页Pharmacy Information

摘　　要：目的:讨论药动学/药效学(PK/PD)的参数AUC/MIC的定义、单位的混乱局面。方法:查阅国内外有关文献,作数理推导并与国内文献进行比对。结果与结论:AUC/MIC的定义和单位国内外文献有三种,到现在还没有定下来。在使用该参数时,必须给出是哪一种定义和单位,以便实验室、临床上进行操作。Objective: To discuss the chaos about the definition and unit of parameter AUC/MIC of the phar-macokinetics/pharmacodynamics (PK/PD). Method: The related literature at home and abroad has been reviewed, and then we made mathematical derivation compared with the domestic literature. Results and Conclusion: There are three kinds of definition and unit of AUC/MIC in the literature at home and abroad, which have not been decided until now. When using the parameter, its definition and unit must be given, in order for the laboratory operation, and clinical use.

关 键 词：药动学/药效学 AUC/MIC AUIC 

分 类 号：R96[医药卫生—药理学]