黑豆黑米茯苓配方的降脂作用与成分分析  

Hypolipidemic Effect of Black Bean Black Rice Poria Formula and Analysis on Its Components

作　　者：潘胜军[1] 邱华锋[1] 李丽蓉[1] 杨铁骊[1] 宋俊香[1] 马建民 

机构地区：[1]黄淮学院人体机能研究中心,河南驻马店

出　　处：《药物资讯》2017年第3期72-77,共6页Pharmacy Information

基　　金：河南省科技攻关项目(项目编号:112102310133,122102310263);河南省国际合作项目(项目编号:134300510023);驻马店市科技攻关项目(编号:12305)资助;黄淮学院俞淼博士在光谱扫描实验中的技术支持。

摘　　要：目的:观察黑豆黑米茯苓原粮配方的降脂效果与成分分析。方法:分光光度法测定降脂粉剂的成分。高血脂患者30例,服用上述降脂配方20天,检测使用降脂粉剂前后的血脂变化。实验性雌性小白鼠30只,分对照组(C)、高脂饲料喂养组(HFD)、高脂饲料加降脂粉剂喂养组(LLP)一周后,检测血脂的变化。结果:降脂粉剂异黄酮含量为3.8% (3.8% &#177;0.5%);高血脂患者的降脂有效率达96.7%,甘油三酯(TG)、总胆固醇(TC)有显著降低(p <0.05),低密度脂蛋白(LDL)轻度降低,高密度脂蛋白(HDL)轻度升高。高脂饲料加降脂粉剂喂养组小白鼠的TC比高脂饲料喂养组显著降低(p <0.01)。结论:黑豆黑米茯苓配方降脂粉剂富含异黄酮,对高血脂患者和实验性高胆固醇小白鼠有明确的降脂效果,可以安全有效地用于降血脂治疗,其有效成分值得进一步研究。Objective: To observe the lipid-lowering effect of black beans and black rice poria formula and analysis its effective components. Methods: Components analysis was done by spectrophotometry. 30 cases of patients with high blood lipids, taking the lipid-lowering formula powder for 20 days, with the detection of blood lipid changes before and after lipid-lowering powder taking. 30 experimental mouse, were randomly divided into control (C) group, high fat diet (HFD) group, high fat diet plus lipid-lowering powder (LLP) feeding group for a week, detecting the change of blood lipid. Result: The content of isoflavone was 3.8% (3.8% &#177;0.5%) in the formula. In patients with hyperlipidemia, the total effective rate of the lipid-lowering powder was 96.7%, triglyceride (TG), total cholesterol (TC) decreased significantly (p

关 键 词：降脂粉剂 高血脂 异黄酮 

分 类 号：R5[医药卫生—内科学]