工艺优化前后通脉降脂片无机元素成分比较分析  

Comparative Analysis of Inorganic Elements in Process Optimization of Tongmai Jiangzhi Tablet

作　　者：魏琦岩 武兵 郑月 闫立成 张喆[4] 唐纪琳[4] 马吉胜 

机构地区：[1]长春三德天晟科技有限公司,吉林长春 [2]吉林农业大学,吉林长春 [3]比智高药业有限公司,吉林四平 [4]中国科学院长春应用化学研究所,电分析化学国家重点实验室,吉林长春

出　　处：《药物资讯》2019年第4期161-164,共4页Pharmacy Information

基　　金：吉林省科技发展计划项目资助(编号:201603010YY).

摘　　要：目的:研究工艺优化前后通脉降脂片中无机元素的含量及组成成分。方法:采用检出限低、线性范围宽、干扰少、灵敏度高的电感耦合等离子体质谱技术进行分析检测。结果:检测到通脉降脂片中含有20种无机元素,其中包括高含量的Ca、Zn和Mg等常量元素,同时也发现样品中含有丰富的Cu、Ba、Se和Mn等微量元素。结论:通脉降脂片中含有多种微量元素,确认无机元素是通脉降脂片治疗高脂血症及防治动脉粥样硬化等症状药效基础的重要组成部分,工艺优化前后与降脂相关的微量元素含量有明显的提高。Objective:To study the content and composition changes of inorganic elements in the Tongmai Jiangzhi Tablet after its process optimization.Methods:Inductively Coupled Plasma Mass Spectrometry,ICP-MS,with low detection limit,wide linear range,low interference and high sensitivity was used for analysis and detection.Results:20 inorganic elements were discovered,including high content of common elements,such as Ca,Zn and Mg.Other trace elements found abundant such as Cu,Ba,Se,Mn were also detected in the samples.Conclusions:The results confirmed that inorganic elements were important parts of material basis of this product affected on hyperlipidemia and atherosclerosis.There is an obvious increase of some inorganic elements related to lipid metabolism.

关 键 词：通脉降脂片 无机元素 高脂血症 

分 类 号：R28[医药卫生—中药学]