谱效关系在中药抗炎药效物质基础研究中的应用进展  

Application Progress of Spectrum-Effect Relationship in the Material Basis Research of Anti-Inflammatory Effect of Traditional Chinese Medicine

作　　者：张京华 夏玉凤 

机构地区：[1]中国药科大学中药学院生药学系,江苏 南京

出　　处：《药物资讯》2022年第2期95-101,共7页Pharmacy Information

摘　　要：中药谱效关系是中药药效物质基础研究的新思路,主要研究方法为采用合适的分析手段构建中药指纹图谱,并对指纹图谱中的成分进行分析,同时建立合适的药效评价模型,获取药效学数据,然后采用一定的数据处理技术使“谱”与“效”相关联来阐释所含化学成分与药效之间的相互关系,从而阐明中药中的药效物质基础。炎症是许多疾病的发病基础,中药因具有良好的抗炎作用而广受关注,但由于中药成分的复杂性,其抗炎作用的药效物质基础一直是现代中药研究中的难点。本文综述近年来从谱效关系的角度探索中药抗炎活性成分的成果,以期为中药抗炎药效物质基础的研究思路提供参考。Spectrum-effect relationship of traditional Chinese medicine (TCM) is a new idea of research on the basis of pharmacodynamics of Chinese herbal. The main research methods are as follows: firstly, the fingerprint of TCM was constructed by appropriate analysis methods, the components were analyzed subsequently. Meanwhile, a suitable pharmacodynamic evaluation model was established to obtain the pharmacodynamic data. The suitable data processing technology was used to correlate “spectrum” and “effect”, and the relationship between the chemical components contained and the efficacy was further explained, so as to clarify the material basis of efficacy in TCM. Inflammation is the basis for the pathogenesis of many diseases. TCM has attracted widely attention because of its good anti-inflammatory effect. However, due to the complexity of Chinese herbal ingredients, the pharmacodynamic material basis of its anti-inflammatory effect has always been a difficulty in modern herbal research. This paper reviews the recent achievements in exploring the anti-inflammatory active ingredients of TCM from the perspective of spectrum-effect relationship, which provides a reference for the research ideas on the material basis of anti-inflammatory.

关 键 词：谱效关系 指纹图谱 抗炎 药效物质基础 

分 类 号：R28[医药卫生—中药学]