细胞代谢组学在中药作用机制中的研究概况  

Research Overview of Cell Metabonomics in the Mechanism of Traditional Chinese Medicine

作　　者：袁静 夏玉凤 

机构地区：[1]中国药科大学中药学院生药学系,江苏 南京

出　　处：《药物资讯》2022年第3期216-223,共8页Pharmacy Information

摘　　要：近年来,中药因其低毒高效的特性受到诸多学者的广泛关注。然而,成分复杂,作用靶点多,作用机制不明确使中药的发展极大受限。细胞代谢组学作为代谢组学一个新的研究方向,将研究系统从生物整体水平缩小到细胞整体水平,可直观反映药物刺激对某种细胞代谢的直接影响,从而更直接地体现中药作用及更有针对性地解释中药作用机制。本文对借助细胞代谢组学探索中药作用机制的概况进行综述,以期为中药作用机制探索提供参考。In recent years, traditional Chinese medicine has been widely concerned by many scholars due to its low toxicity and high efficiency. However, the development of traditional Chinese medicine is greatly restricted owing to its complex composition, numerous targets, and unclear mechanism. As a new research direction of metabolomics, cell metabolomics narrows the research system from the overall level of biology to the overall level of cells, which can intuitively reflect the direct impact of drug stimulation on the metabolism of a certain cell, so as to more directly reflect the effects and explain the mechanism of Chinese medicines in a more targeted manner. This paper reviews the general situation of exploring the mechanism of traditional Chinese medicine by means of cell metabolomics, in order to provide reference for the exploration of the mechanism of traditional Chinese medicine.

关 键 词：细胞代谢组学 中药 作用机制 

分 类 号：R28[医药卫生—中药学]