三七多糖面膜贴的研究开发  

Research and Development of Panax notoginseng Polysaccharide Facial Mask Paste

作　　者：周家明[1] 宋春蕊 欧景春 马妮[1] 王朝梁[1] 

机构地区：[1]文山学院三七医药学院,云南 文山

出　　处：《药物资讯》2022年第4期267-277,共11页Pharmacy Information

摘　　要：目的:以三七多糖为主要活性原料,加入白芨、苦参提取物等中药原料共同配制出一款补水保湿,抗衰老的面膜贴。方法:采用水提醇沉法从三七主根中提取三七多糖,在分别采用水回流法和乙醇回流法从白芨和苦参中提取主要活性物质,最后浓缩干燥得到白芨提取物和苦参提取物。通过单因素实验和正交实验确定三七多糖面膜贴的最佳工艺配方。结果:三七多糖面膜贴的最佳配方为:三七多糖2 g,白芨提取物1 g,苦参提取物1 g,汉生胶0.05 g,羧甲基纤维素钠1 g,甘油7 g等辅料,加纯化水至100 ml。所得面膜贴的保湿率大于85.12%,对清除DPPH自由基的能力能达到75.2%,能够很好的抑制大肠杆菌和金黄色葡萄球菌的滋生。结论:通过稳定性考察得到三七多糖面膜贴PH值接近人体PH值在6~7之间,使用后明显感到温和舒适、滋润。达到了补水保湿抗衰老的功效。Objective: With Panax notoginseng polysaccharide as the main active raw material, add Bletilla striata extract, bitter ginseng extract, and other traditional Chinese medicine ingredients to make a hydrating and moisturizing, anti-aging mask paste. Method: Panax notoginseng polysaccharides were extracted from notoginseng main roots by water extraction, and the main active substances were extracted from Bletilla and ginseng by water reflux and ethanol reflux, respectively, and the extract was concentrated and dried. The optimal process formula of Panax notoginseng polysaccha-ride mask paste was determined by univariate experiments and orthogonal experiments. Results: The best formula for notoginseng polysaccharide mask was: Panax notoginseng polysaccharides 2 g, Bletilla striata extract 1 g, bitter ginseng extract 1 g, hanson gum 0.05 g, 1 g sodium carboxymethyl cellulose, and 7 g glycerol, adding purified water to 100 ml. The moisturizing rate of the obtained facial mask paste is greater than 85.12%, and the ability to remove DPPH free radicals reaches 75.2%, which can well inhibit the growth of E. coli and S. aureus. Conclusion: Through the stability investigation, the PH value of Panax notoginseng polysaccharide mask is close to the PH value of the human body, and it is between 6 and 7, which is obviously mild, comfortable, and moist after use. It has the effect of moisturizing and anti-aging.

关 键 词：三七多糖 补水保湿 抗衰老 稳定性 

分 类 号：R28[医药卫生—中药学]