CYP450底物、抑制剂、诱导剂及种属特异性的研究进展  

Research Progress of CYP450 Substrates, Inhibitors, Inducers and Species Specificity

作　　者：刘永敏 夏玉凤 

机构地区：[1]中国药科大学中药学院生药学系,江苏 南京

出　　处：《药物资讯》2023年第2期70-80,共11页Pharmacy Information

摘　　要：细胞色素P450是由多种同工酶组成的超家族,在内源性与外源性物质的I相代谢中占据主导地位。本文就细胞色素P450同工酶相关的探针底物、抑制剂、诱导剂及动物种属的特异性选择进行了综述,以期为细胞色素P450相关实验设计提供借鉴和参考。Cytochrome P450 is a superfamily composed of multiple isoenzymes, which plays a dominant role in phase I metabolism of endogenous and exogenous substances. This review included the specific of probe substrates, inhibitors, inducers and species related to cytochrome P450 isoenzymes, in order to provide reference for the design of cytochrome P450 related experiments.

关 键 词：细胞色素P450 抑制剂 诱导剂 探针底物 种属差异 

分 类 号：TS2[轻工技术与工程—食品科学与工程]