双指标正交实验优选临方腰痛丸制备工艺  

Optimization of Preparation Process for Lin-fang Lumbago Pills by Dual Indicator Orthogonal Experiment

作　　者：弓剑升 秦萍 胡萍 

机构地区：[1]无锡市中医医院药学部,江苏 无锡

出　　处：《药物资讯》2023年第4期370-374,共5页Pharmacy Information

摘　　要：目的:优选临方腰痛丸的最佳制备工艺。方法:以丸剂崩解时限和成品报废率为评价指标,选择干燥温度,丸剂粒径,粉末粗细为考察因素,采用L9(3)3正交实验法确定临方腰痛丸最佳制备工艺。结果:正交实验结果表明,粉末粗细为60目,干燥温度为60℃,粒径大小为3 mm时,为临方腰痛丸最佳制备工艺。结论:优选出的制备方法结果可靠、稳定可行,为其他丸剂品种的制备工艺的优化提供参考。Objective: This paper aims to study the optimum extraction process of Pill for lumbago. Methods: The Disintegration time limit and scrap rate of finished products were selected as quality index. The influencing factors such as drying temperature, pill size and powder size were optimized by or-thogonal L9(3)3 design experiment to screen out the best Preparation process. Results: The optimal procedure was set as follows: The size of the powder is 60 mesh;drying temperature 60˚C;particle size 3 mm. Conclusion: The technology is reasonable, stable and viable.

关 键 词：丸剂 正交实验 崩解时限 

分 类 号：R28[医药卫生—中药学]