基于近红外光谱结合化学计量学的复方感冒灵颗粒原药材南板蓝根中水分的检测研究  

Detection of Moisture in Radix Isatidis of Compound Ganmaoling Granules Based on Near Infrared Spectroscopy and Stoichiometry

作　　者：龙洪 李蕴韬 陆美清 杨一栋 蓝武青 张涛 金超城 

机构地区：[1]华润三九(郴州)制药有限公司,湖南 郴州

出　　处：《药物资讯》2024年第1期10-15,共6页Pharmacy Information

摘　　要：目的:本研究旨在建立近红外光谱法快速检测复方感冒灵颗粒原药材南板蓝根中水分的方法。方法:通过近红外光谱仪对复方感冒灵颗粒原药材南板蓝根药材粉末进行扫描,使用一阶导数的预处理方法,结合PLS方法建立南板蓝根水分定量模型。结果:相关系数R为0.9022,RMSEC = 0.1683,预测值和实际值之间没有明显的差异(P > 0.05)。结论:该方法建立的水分定量模型,适用于复方感冒灵颗粒原药材南板蓝根的水分的快速检测。Objective: The purpose of this study was to establish a method for rapid detection of water in Radix Isatidis of Compound Ganmaoling Granules by near infrared spectroscopy. Methods: The powder of Radix Isatidis, the original medicinal material of Compound Ganmaoling Granules, was scanned by near infrared spectrometer. The quantitative model of Radix Isatidis moisture was established by using the first derivative pretreatment method and PLS method. Results: The correlation coefficient R was 0.9022, RMSEC = 0.1683, and there was no significant difference between the predicted value and the actual value (P > 0.05). Conclusion: The quantitative model of moisture established by this method is suitable for the rapid detection of moisture in Radix Isatidis of Compound Ganmaoling Granules.

关 键 词：复方感冒灵颗粒 南板蓝根 水分 定量模型 近红外光谱技术 偏最小二乘法 

分 类 号：R28[医药卫生—中药学]