龙胆科植物来源的化合物抗炎作用机制研究进展  

Research Progress on Anti-Inflammatory Mechanisms of Compounds from Gentiaceae Plants

作　　者：彭学容 朱钰珊 范苏苏 孙亚茹 王洋 张旋 

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室/现代生物医药产业学院,云南 昆明 [2]昆明市延安医院药学部,云南 昆明

出　　处：《药物资讯》2024年第1期25-32,共8页Pharmacy Information

摘　　要：龙胆科(Gentianaceae)植物是一类广泛分布于全球的药用植物,其主要活性成分为龙胆苦苷、獐芽菜苷、獐芽菜苦苷以及生物碱、黄酮、香豆素及内酯等化合物。龙胆科植物来源的化合物具有显著的抗炎作用,可以通过多种途径调节炎症反应,对于治疗各种炎症相关疾病具有重要的意义。本文综述了龙胆科植物来源的化合物抗炎作用的主要机制,包括抑制转录因子的激活;抑制炎症相关酶的表达;减少炎症介质的产生;调节免疫细胞的功能;以及影响自噬和NLRP3等新兴机制,旨在为龙胆科植物来源的化合物在炎症性疾病中的应用提供一定的参考。Gentianaceae is a kind of medicinal plants widely distributed in the world. Its main active compo-nents are gentiopicroside, swertiamarin, sweroside, alkaloids, flavonoids, coumarins and lactones. Compounds from Gentianaceae plants have significant anti-inflammatory effects, can regulate in-flammatory response through a variety of ways, and is of great significance for the treatment of var-ious inflammation-related diseases. This paper reviewed the main mechanisms of anti-inflammatory effects of compounds from Gentianaceae plants, including in hibiting the activation of transcription factors, down regulating the expression of inflammation-related enzymes, reducing the production of inflammatory mediators, regulating the function of immune cells, as well as affecting autophagy and NLRP3, the aim is to provide references for application of compounds from Gentianaceae plantsin inflammatory diseases.

关 键 词：龙胆科植物 活性成分 炎症 抗炎机制 

分 类 号：R28[医药卫生—中药学]