异腈参与的多组分反应新进展  

New Progresses of Multicomponent Reactions Based on Isocyanides

作　　者：靳文静 韩光[1] 何心伟[1] 胡凯 商永嘉[1] Wenjing Jin;Guang Han;Xinwei He;Kai Hu;Yongjia Shang(The Key Laboratory of Functional Molecular Solids Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu)

机构地区：[1]安徽师范大学,化学与材料科学学院,功能分子固体教育部重点实验室,芜湖

出　　处：《合成化学研究》2014年第1期11-22,共12页Studies in Synthetic Chemistry

基　　金：国家自然科学基金(No.21172001,21372008);教育部新世纪优秀人才计划(No.NCET-10-0004);安徽省自然科学基金(No.1308085QB39)资助项目。

摘　　要：本文综述了异腈参与的多组分反应合成一些杂环化合物的最新研究进展,主要介绍了异腈参与的Ugi多组分反应的几种新型反应,详细地介绍了各种反应对底物的要求、反应条件、反应的选择性、产率以及机理的研究。同时对近年来发展的异腈参与的几种新型Passerini多组分反应进行了简单介绍。对异腈参与的多组分反应合成杂环化合物的前景进行了展望。This paper reviewed the new progresses of the multicomponent reactions based on isocyanides to synthesize the heterocyclic compounds, and mainly introduced some new reactions of the Ugi multicomponent reactions. The request of substrates, reaction conditions, selectivity, yield and mechanism were investigated in detail. Meanwhile, a brief introduction of some new Passerini multicomponent reactions was given. New breakthroughs in this field were intensely expected.

关 键 词：异腈 多组分反应 组合化学 杂环化合物 

分 类 号：O62[理学—有机化学]