醋酸钴/TBHP催化氧化取代甲苯反应的研究  

Study on Cobalt Acetate/TBHP Catalyzed Oxidation of Substituted Toluenes

作　　者：裴明明 吴江龙 刘平 刘岩 马晓伟 

机构地区：[1]石河子大学化学化工学院/新疆兵团化工绿色过程重点实验室,新疆石河子

出　　处：《合成化学研究》2017年第3期13-19,共7页Studies in Synthetic Chemistry

基　　金：国家自然科学基金(No.21463022);石河子大学杰出青年科技人才培育计划(No.2014ZRKXJQ05)对本工作的支持。

摘　　要：苯甲酸及其衍生物作为一类重要的有机化工中间体,广泛用于生产医药、香料和食品防腐剂等生产中。本文通过在常压、无溶剂条件下,过氧化叔丁醇(TBHP)和醋酸钴结合催化氧化取代甲苯合成了一系列苯甲酸衍生物,确定了催化取代甲苯氧化合成苯甲酸类衍生物的最优反应条件为:1 mol% Co(OAc)2?4H2O,3当量的TBHP,取代甲苯5 mL,反应温度为100℃,反应时间为24 h。该方法具有选择性高,反应条件温和,催化剂廉价易得,分离简单,底物适用范围广等优点。Benzoic acid and its derivatives as an important class of organic chemical intermediates, is widely used in the production of pharmaceutical, perfume and food preservatives. In this paper, tert- butyl hydroperoxide (TBHP) and cobalt acetate combined catalytic oxidation of substituted toluene synthesized a series of benzoic acid derivative at atmospheric pressure in the absence of solvent, and identified the catalytic oxidation of toluene substituted to benzoic acid derivatives. The optimal reaction conditions were as follow: 1 mol% Co(OAc)2?4H2O, 3 equivalents of TBHP, 5 mL of toluene, reaction temperature 100?C, reaction time 24 h. The method has many advantages of high selectivity, mild reaction conditions, cheap and readily available catalyst, simple separation, a wide suitable range of substrates.

关 键 词：甲苯 过氧化叔丁醇 醋酸钴 氧化 

分 类 号：O64[理学—物理化学]