L-脯氨酸衍生的新型硫脲催化剂催化苯甲醛的加成烷基化  

L-Proline Derived New Thiourea Catalysts Catalyzed Addition Alkylation of Benzaldehyde

作　　者：贾俊 刘国桂 王兴旺[2] 

机构地区：[1]苏州大学,分析测试中心,江苏 苏州 [2]苏州大学,材料与化学化工学部,江苏 苏州

出　　处：《合成化学研究》2020年第1期25-32,共8页Studies in Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21272166)。

摘　　要：本文以L-脯氨酸衍生的手性硫脲为催化剂,对苯甲醛与二乙基锌的不对称1,2-加成烷基化反应进行了研究。我们发现在最优化的催化剂反应条件下,该反应可以以高收率和中等的对映选择性得到1-苯基-1-丙醇化合物。该催化体系具有高效、低成本、反应条件温和等特点,为合成手性芳基醇类化合物提供了一条有效、方便的路径。In this paper, a series of L-proline derived chiral thioureas were designed and synthesized. Then the resulting catalysts were applied into the 1,2-addition reation of diethylzinc to benzaldehyde, which provided 1-phenylpropan-1-ol with good to excellent yields, albeit with moderate enatioselectivity. The catalytic system is featured with high efficiency, low cost as well as mild reaction conditions, and it was proved to be an effective and convenient route for the synthesis of chiral aromatic alcohols.

关 键 词：不对称催化 手性硫脲 1 2-加成 二乙基锌 手性醇 

分 类 号：O62[理学—有机化学]