中医复方治疗糖尿病肾病的药理研究及临床实践  

Pharmacological Research and Clinical Trial of Chinese Medicine Compound to Treat Diabetic Nephropathy

作　　者：陈立义 叶俊宏 温熙 文曦儿 廖冠雄 刘明艺 张俊曦 黄历恒 石军 邓智伟 张樟进[1] 孟炜[1] 何柏婵 张艳波[1] 

机构地区：[1]香港大学中医药学院,香港 [2]香港大学李嘉诚医学院,内科系及玛丽医院,香港

出　　处：《中医学》2018年第6期407-413,共7页Traditional Chinese Medicine

基　　金：香港政府创新科技署创新科技基金委员创新科技支持项目,号码No.UIM/321。

摘　　要：本文目的是探讨中医复方治疗糖尿病肾病的研究进展及临床实践,以便更好的指导临床用药。糖尿病肾病的主要中医病机是肾虚络瘀,中药复方治疗糖尿病肾病已经通过药理和临床的方法被研究,包括复方糖肾方、补阳还五汤、真武汤等。更有对该病的药物作用机理也被探索,这对正确评价中医药疗效有重要意义。研究结果显示中医药可从多途径治疗糖尿病肾病,包括减少ECM (extracellular matrix) 沉积、改善免疫应答、提高抗氧化能力以抑制氧化应激、抑制炎性反应、保护血管内皮细胞功能等,治疗作用显著。This study purposes to explore the research progress and clinical trial of Chinese medicine com-pound in the treatment of diabetic nephropathy (DN) for guiding to clinical medication at the present. DN is a kidney damage results from long term diabetes. The basic pathogenesis of DN is Shen-xu-luo-yu (Stagnation of blood stasis in kidney collateral due to kidney deficiency) according to the theory of Chinese medicine. Some Chinese medicine compounds for DN have been investigated including Tang Shen Fang, Bu Yang Huan Wu Decoction, Zhen Wu Decoction and so on. Moreover, the action mechanism of Chinese medicine compounds in DN has also been explored. This is very important for evaluating the efficacy of Chinese medicine compound for DN. The study results show that Chinese medicine compounds treat DN in many ways, including reducing ECM (extracellular matrix) deposition, improving immune response, increasing antioxidant capacity to inhibit oxidative stress, repressing inflammatory response and protect vascular endothelial cell function.

关 键 词：糖尿病肾病 中医复方 药理 临床实践 

分 类 号：R2[医药卫生—中医学]