O型血孕妇口服中药对降低新生儿ABO溶血症的价值研究  

Study on the Value of Oral Chinese Medicine in Reducing ABO Hemolysis of Newborn in Pregnant Women with Blood Type O

作　　者：邹芳[1] 程平平[2] 祝佩 黄艳 严丽丽 

机构地区：[1]江西省妇幼保健院新生儿科,江西 南昌 [2]南昌市洪都中医院麻醉科,江西 南昌 [3]江西省妇幼保健院中医科,江西 南昌 [4]江西省妇幼保健院产科,江西 南昌

出　　处：《中医学》2023年第7期1839-1844,共6页Traditional Chinese Medicine

摘　　要：目的:从中医学“治未病”角度探讨孕期中药干预O型血孕妇抗-A或抗-B效价对新生儿生后溶血病、黄疸的影响。方法:选择2021年01月至2021年12月期间我院门诊O型血孕妇查抗A或抗B效 > 1:64的孕妇120例,采用随机数字表法分为两组,每组各60例。实验组予口服中药干预,对照组不予干预,监测抗体效价,待新生儿分娩后追踪新生儿近期出现黄疸、溶血病、贫血等疾病情况,结果:溶血病检测中:实验组新生儿直抗试验阳性率8.3%,对照组22%,差异有统计学意义,实验组新生儿游离试验阳性率10%,对照组25%,差异有统计学意义,实验组新生儿放散试验阳性率6.6%,对照组20%,差异有统计学意义。实验组总胆红素峰值167.83 ± 19.72,对照组总胆红素峰值201.64 ± 22.37,差异有统计学意义。实验组贫血发病率15%,对照组20%,差异无统计学意义。实验组高胆红素血症发病率31%,对照组56%,差异有统计学意义。实验组与对照组患儿贫血需输血率(3.3% vs 1.6%,校正χ2 = 0.342,P = 0.559)及高胆红素血症需换血率(3.3% vs 6.6%,校正χ2 = 0.702,P = 0.402)比较差异无统计学意义(P > 0.05)。结论:O型血孕妇孕期口服中药干预抗体效价可以降低新生儿溶血病发病率及高胆红素血症发病率,但并未降低溶血病换血率及贫血输血率。Objective: To investigate the effect of Chinese medicine intervention of anti-A or anti-B titer in pregnant women with type O blood on neonatal hemolytic disease and jaundice. Methods: From January 2021 to December 2021, 120 pregnant women with type O blood whose anti-A or anti-B effect was >1:64 were selected and divided into two groups by random number table method, with 60 cases in each group. The experimental group was given oral Chinese medicine intervention, while the control group was not given intervention. Antibody titer was monitored. The recent occurrence of jaundice, hemolytic disease, anemia and other diseases of the newborn were tracked after delivery. Results: The positive rate of direct resistance test was 8.3% in the experimental group and 22% in the control group, the positive rate of neonatal free test was 10% in the experimental group and 25% in the control group, the positive rate of neonatal free test was 6.6% in the experimental group and 20% in the control group, the difference was statistically significant. The peak value of total bilirubin in the experimental group was 167.83 ± 19.72, and that in the control group was 201.64 ± 22.37, the difference was statistically significant. The incidence of anemia was 15% in the experimental group and 20% in the control group, the difference was not statistically significant. The incidence of hyperbilirubinemia was 31% in the experimental group and 56% in the control group, the difference was statistically significant. The rate of anemia requiring blood transfusion (3.3% vs 1.6%, χ2 = 0.342, P = 0.559) and the rate of hyperbilirubinemia requiring blood exchange (3.3% vs 6.6%, χ2 = 0.702, χ2 = 0.702) in the experimental group and the control group. P = 0.402) There was no statistically significant difference (P > 0.05). Conclusion: Oral intervention with antibody titer of Chinese medicine during pregnancy can reduce the incidence of neonatal hemolytic disease and hyperbilirubinemia, but it does not reduce the rate of hemolytic disease exchange a

关 键 词：新生儿 治未病 中药 O型血孕妇 抗体效价 疗效 

分 类 号：R47[医药卫生—护理学]