基于相关信号通路中医药干预急性胰腺炎的可视化分析  

Visual Analysis of Chinese Medicine Intervention in Acute Pancreatitis Based on Relevant Signaling Pathways

作　　者：梁岑怡 祖悦 辛宛铃 李偲嘉 王宁[1,2] 陈国忠 

机构地区：[1]广西中医药大学研究生院,广西 南宁 [2]广西中医药大学第一附属医院脾胃一区,广西 南宁

出　　处：《中医学》2023年第7期1867-1877,共11页Traditional Chinese Medicine

摘　　要：目的:分析中医药介导相关信号通路干预急性胰腺炎(AP)的相关文献,了解该领域的研究热点及前沿趋势。方法:检索中国知网(CNKI)、万方数据库、重庆维普数据库(VIP)收录的2001年01月01日~2023年03月19日基于相关信号通路中医药干预急性胰腺炎的文献,采用NoteExpress、Excel、CiteSpace分别进行筛选、绘制发文趋势折线图以及绘制核心作者机构视图及关键词共现、聚类、突现、时间线图谱,并分析。结果:共纳入文献361篇,年发文量总体呈上升趋势,主要发表于《中国中医急症》(16篇)、《世界华人消化杂志》(10篇)等,共涉及521位作者,并形成了以陈国忠、唐文富、张延英、兑丹华等为代表的研究团队。文献关键词形成了10个有意义的聚类,显示该领域研究热点主要集中于大承汤、大黄、细胞凋亡等;备受关注的中医药干预手段有大柴胡汤、活血化瘀汤、清解化攻方、甘遂、大黄素、黄芩素、针灸、电针等,主要涉及NF-κB、MAPK (包括P38mapk、JNK、ERK)、TLR-4、JAK2/STAT3、细胞凋亡等信号通路的研究。结论:中医药调控信号通路干预AP的研究近年热度较高,但高层次研究仍需研究团队间的交流与合作。研究热点主要涉及4个方面:中医药干预通路AP所调控的生化指标、细胞因子;信号通路;研究对象及中医药干预手段的更新与发展。Objective: To analyze the literature on traditional Chinese medicine-mediated signaling pathway interventions in acute pancreatitis (AP) to understand the hot spots and cutting-edge trends in this field of research. Methods: CNKI, Wanfang Data, and VIP were searched for literature related to research on TCM intervention acute pancreatitis based on relevant signaling pathways from January 01, 2001, to Mar 19, 2023, and the literature was de-weighted and manually screened using NoteExpress. A line graph of publication trends was drawn using Excel. CiteSpace software was used to draw and analyze the map of co-occurrence, clustering, emergence and timeline of keywords. Results: A total of 361 articles were included, and the annual volume of articles was on the rise, mainly published in Emergency of Chinese Medicine (16 articles) and World Journal of Chinese Digestion (10 articles), involving 521 authors, and formed a research team represented by Chen Guozhong, Tang Wenfu, Zhang Yanying, Dui Danhua and so on. The keywords in the literature form 10 meaningful clusters, indicating that the research hotspots in this field mainly focus on dachengtang, rhubarb, apoptosis and so on Traditional Chinese medicine (TCM) interventions of great concern include da Chai Hu Tang, Huo Xue Hua Yu Tang, Qing Jie Hua Gong Fang, Euphorbia kansui, Emodin, Baicalein, acupuncture, electro-acupuncture, etc. NF-κb, MAPK (including P38mapk, JNK, ERK), TLR-4, JAK2/STAT3, apoptosis and other signaling pathways are involved. Conclusion: In recent years, the study on the intervention of the signaling pathway of TCM to AP has been hot, but the high-level research still needs the communication and cooperation among research teams. The research focuses mainly on four aspects: biochemical indexes and cytokines regulated by AP, signal pathway, research objects and the renewal and development of TCM intervention methods.

关 键 词：中医药 信号通路 急性胰腺炎 CITESPACE 研究热点 

分 类 号：R28[医药卫生—中药学]