基于数据挖掘研究中药治疗月经过少(肾虚型)的用药规律  

Study on the Medication Rule of Chinese Medicine in the Treatment of Hypomenorrhea (Kidney Deficiency Type) Based on Data Mining

作　　者：王燕玲 曲秀芬[2] 王聪聪 韩艺源 

机构地区：[1]黑龙江中医药大学第一临床医学院,黑龙江 哈尔滨 [2]黑龙江中医药大学附属第一医院,黑龙江 哈尔滨

出　　处：《中医学》2023年第11期3355-3362,共8页Traditional Chinese Medicine

摘　　要：目的:运用统计学方法研究中药治疗月经过少(肾虚型)的用药规律,探讨现代医家治疗月经过少的用药特点及配伍意义,挖掘临床常用的药物组成及药对,为临床诊治月经过少提供参考。方法:通过检索中国知网(CNKI)、维普(VIP)、万方(Wanfang)等数据库,根据纳排标准,筛选出符合标准的病例,建立数据库,运用SPSS Modeler 18.0、SPSS Statistics 26.0软件,对药物关联规则及聚类进行分析。结果:研究纳入病历124例,涉及中药150味,使用频率较高的药物有29味(频次 ≥ 20次),排前5的药物分别为当归、熟地黄、菟丝子、白芍、枸杞子。中药性味归经统计中,药性以温为主,味以甘、苦多见,归经则肝经最频;药物关联规则分析得到置信度 ≥ 90%的两项关联药物组合11组;聚类分析得出6类药物聚合组。结论:中医药治疗肾虚型月经过少以补血养血益肾为主,根据兼症的不同,佐以疏肝、健脾、活血、化瘀等药物。Objective: To study the medication rule of traditional Chinese medicine in the treatment of hypo-menorrhea (kidney deficiency type) by statistical methods, to explore the drug use characteristics and compatibility significance of modern doctors in the treatment of hypomenorrhea, to explore the commonly used drug composition and drug pair in clinical practice, and to provide reference for clinical diagnosis and treatment of hypomenorrhea. Methods: By searching CNKI, VIP, Wanfang and other databases, the patients meeting the criteria were selected according to the included and ex-cluded criteria, and the database was established. SPSS Modeler 18.0 and SPSS Statistics 26.0 were used to analyze drug association rules and clustering. Results: 124 cases of medical records were included in this study, involving 150 traditional Chinese medicines, 29 drugs with high frequency of use (frequency ≥ 20 times), top 5 drugs were Angelica sinensis, Rehmannia glutinosa, cuscuta seed, white paeony and wolfberry. According to the statistics of TCM flavor normalization, the nature of medicine is mainly warm, and the taste is sweet and bitter. The liver meridian normalization is the most frequent. 11 groups of two associated drug combinations with confidence ≥90% were obtained by drug association rule analysis. Six drug polymerization groups were obtained by cluster analysis. Conclusion: Traditional Chinese medicine is mainly used to nourish the blood and the kidney in the treatment of kidney deficiency type hypomenorrhea. According to the different concomitant dis-eases, drugs such as soothing the liver, invigorating the spleen, promoting blood circulation and removing blood stasis are used.

关 键 词：月经过少 数据挖掘 用药规律 关联规则 聚类分析不然 

分 类 号：R28[医药卫生—中药学]