基于TyG指数对益气健脾汤治疗2型糖尿病胰岛素抵抗的临床疗效观察  

Clinical Efficacy Observation of Replenishing Qi to Invigorate the Spleen Decoction in the Treatment of Insulin Resistance in Type 2 Diabetes Mellitus Based on the TyG Index

作　　者：李爱平 田源[2] 

机构地区：[1]黑龙江中医药大学研究生院,黑龙江 哈尔滨 [2]黑龙江中医药大学附属第三医院内分泌科,黑龙江 哈尔滨

出　　处：《中医学》2024年第12期3290-3296,共7页Traditional Chinese Medicine

基　　金：2017年教育厅优秀创新人才项目(UNPYSCT-2017227);2022年黑龙江中医药管理局科研项目(ZHY2022-199)。

摘　　要：目的:观察益气健脾汤治疗2型糖尿病胰岛素抵抗的临床疗效,阐述TyG指数对胰岛素抵抗指数的补充作用。方法:选取就诊于本院内分泌老年病科符合2型糖尿病胰岛素抵抗患者60例,随机分组,分为对照组30例和治疗组30例,对照组给予盐酸二甲双胍片,治疗组在对照组治疗的基础上加用益气健脾汤,观察经过8周的治疗后,患者脾气亏虚证候的评分变化,以及与之相关的血糖指标、空腹胰岛素指标、血脂指标和胰岛素抵抗指标(TyG指数、HOMA-IR、TG/HDL-C)的具体改善情况。结果:脾气亏虚证候的评分方面,治疗后的脾气亏虚证候均低于治疗前(p p p p p p p p Objective: To observe the clinical efficacy of replenishing Qi to invigorate the spleen decoction in the treatment of insulin resistance in type 2 diabetes mellitus (spleen qi deficiency type) Methods: 60 patients with type 2 diabetes mellitus insulin resistance were selected from the Department of Endocrinology and Geriatrics of the Third Affiliated Hospital of Heilongjiang University of Chinese Medicine, randomly divided into the control group (n = 30 cases) and the treatment group (n = 30 cases), and the control group was given metformin hydrochloride tablets, and the treatment group was given replenishing Qi to invigorate the spleen decoction on the basis of the control group’s treatment, and the spleen Qi deficiency syndrome scores, blood glucose-related indexes, lipid-related indexes, and insulin resistance-related indexes (including TyG indexes) were observed after 8 weeks of treatment, etc. Results: In terms of spleen Qi deficiency symptoms scores, the scores post-treatment were lower than pre-treatment (p p p p p p p p < 0.05). Conclusion: Replenishing Qi to invigorate the spleen decoction could significantly improve glycolipid metabolism, insulin resistance and improve related TCM symptoms.

关 键 词：TyG指数 糖脂代谢 胰岛素抵抗 益气健脾汤 

分 类 号：R58[医药卫生—内分泌]