基于网络药理学探讨温胆汤对痰浊中阻型后循环缺血性眩晕的作用机制  

The Mechanism of Warm Bile Soup on Circulating Ischemic Vertigo Was Investigated Based on Network Pharmacology

作　　者：温旖蓝 方兴[2] 李蒙 贺天琪 闫雨 

机构地区：[1]广西中医药大学研究生院,广西 南宁 [2]广西中医药大学附属瑞康医院,广西 南宁

出　　处：《中医学》2025年第1期462-469,共8页Traditional Chinese Medicine

摘　　要：本研究旨在利用网络药理学方法预测温胆汤在治疗痰浊中阻型PCIV的潜在作用机制。利用多个数据库、分析平台及文献检索,收集出温胆汤中各中药成分靶点与疾病靶点,取其共同交集靶点,并进行基因本体(GO)和京都基因与基因组百科全书(KEGG)的富集分析,同时使用相关软件分别构建出成分–疾病–通路靶点网络和蛋白质–蛋白质相互作用网络图。经分析筛选后,在温胆汤中发现49种活性化合物,其中与PCIV相关的共139个靶点。药物主要成分包括柚皮苷、槲皮素、木犀草素、黄芩苷,关键核心靶点包括IL6、TNF、STAT3等。KEGG信号通路包括癌症的途径、脂质和动脉粥样硬化、化学致癌作用–受体激活、IL-17信号等。结论:温胆汤对PCIV的治疗作用可能是通过柚皮苷、黄芩苷等成分及调节IL6、TNF等靶点从而参与抗炎、促进脂质代谢等多条途径。This study aimed to predict the potential mechanism of warm bile soup in the treatment of sputum resistant PCIV. Using multiple databases, analysis platform and literature retrieval, collect the Chinese medicine composition targets and disease targets, take the common intersection targets, and gene ontology (GO) and Kyoto gene and genome encyclopedia (KEGG) enrichment analysis, at the same time using the related software to build components-disease-pathway target network and protein-protein interaction network diagram. After analytical screening, 49 active compounds were found in bile soup, including a total of 139 targets associated with PCIV. The main components of the drugs include naringin, quercetin, luteolin, and baicalin, and the key core targets include IL 6, TNF, and STAT 3. KEGG signaling pathways including cancer pathway, lipids and atherosclerosis, chemical carcinogenesis-receptor activation, IL-17 signaling, etc. Conclusion: The therapeutic effect of bile soup on PCIV may be through naringin, baicalin and other components and targets such as IL 6 and TNF

关 键 词：温胆汤 网络药理学 

分 类 号：R28[医药卫生—中药学]