NLRP3信号通路与痛风性关节炎的关系及中医药治疗的研究进展  

The Relationship between NLRP3 Signaling Pathway and Gouty Arthritis and the Research Progress of Chinese Medicine Treatment

作　　者：谭志康 朱英[2] 

机构地区：[1]广西中医药大学研究生院,广西 南宁 [2]广西中医药大学附属瑞康医院针灸科,广西 南宁

出　　处：《中医学》2025年第2期530-538,共9页Traditional Chinese Medicine

摘　　要：痛风性关节炎(GA)是人体内嘌呤代谢紊乱和(或)尿酸排泄异常引起的一组代谢性疾病。其发病原因多与饮食结构、蛋白质、糖、脂肪过多摄入有关。临床表现为关节红肿热痛,严重影响患者日常生活,因此对抗GA的药物等的研究较为迫切。西药治疗GA的药物如秋水仙碱等,虽能在短期内缓解疼痛,但是长期使用不良反应明显;与西药相比,中医药治疗GA疗效确切,安全性强,更易被患者接受。近年来,业界开展了大量研究探索中医药通过调控NOD样受体热蛋白结构域相关蛋白3 (NLRP3)信号通路治疗GA的作用机制。但目前尚缺乏关于中医药调控NLRP3通路进而治疗GA的全面系统的总结。本文简单阐述了NLRP3炎症信号通路与GA发生发展的关系和中医对痛风性关节炎的认识及诊疗经验,并总结了中药有效成分、中药复方及其制剂、中医外治干预NLRP3炎症小体治疗GA的最新研究报道,以期为GA发病机制及药物治疗的深入研究提供新思路,为临床上运用中医药防治GA提供依据。Gouty arthritis (GA) is a metabolic disorder of purine metabolism and/or abnormal uric acid excretion in the body. The etiology is related to excessive intake of diet, protein, sugar and fat. Clinical manifestations of joint redness, swelling, heat and pain, seriously affect the daily life of patients, so anti-GA drug research is more urgent. Western medicine for the treatment of GA, such as colchicine, can relieve pain in a short time, but the adverse reactions of long-term use are obvious. Compared with Western medicine, traditional Chinese medicine in treating GA is more effective, safer and more acceptable to patients. In recent years, many researches have been carried out to explore the mechanism of TCM treating GA by regulating the signal pathway of NOD receptor thermoprotein domain related protein 3 (NLRP3). However, there is still a lack of a comprehensive and systematic summary of TCM regulation of NLRP3 pathway

关 键 词：痛风性关节炎 中医药 信号通路 研究进展 

分 类 号：R28[医药卫生—中药学]