中药葛根防治肥胖的作用机制和研究进展  

Mechanism of Action and Research Progress of Chinese Medicine Pueraria mirifica against Obesity

作　　者：赵文超 王泽宇 马建[2] 

机构地区：[1]黑龙江中医药大学第一临床医学院,黑龙江 哈尔滨 [2]黑龙江中医药大学附属第一医院内分泌科,黑龙江 哈尔滨

出　　处：《中医学》2025年第3期881-888,共8页Traditional Chinese Medicine

摘　　要：肥胖作为全球范围内的重要公共健康问题,其发病率持续上升,严重影响人类健康。中药在肥胖治疗中展现出独特的优势,其中葛根因其丰富的活性成分和多种药理作用备受关注。本文综述了葛根治疗肥胖的相关研究进展,重点分析了葛根的主要活性成分(如葛根素、异黄酮类化合物等)及其在脂质代谢调节、胰岛素敏感性改善、抗炎抗氧化以及肠道菌群调节等方面的作用机制。此外,本文还总结了近年来关于葛根的动物实验及临床研究,探讨了葛根在单独应用或与其他中药联合使用中的治疗潜力及其安全性问题。尽管葛根在肥胖治疗中展现出一定的疗效,但相关研究仍存在局限性,未来的研究需进一步验证其临床疗效并探讨其长期安全性和应用前景。Obesity, as an important public health problem worldwide, has continued to rise in prevalence and seriously affects human health. Traditional Chinese medicine (TCM) has demonstrated unique advantages in the treatment of obesity, among which Pueraria mirifica has attracted much attention due to its rich active ingredients and various pharmacological effects. In this paper, we reviewed the research progress of Pueraria lobata in the treatment of obesity, focusing on the analysis of the main active components of Pueraria lobata (such as puerarin, isoflavones, etc.) and their mechanisms of action in the regulation of lipid metabolism, improvement of insulin sensitivity, anti-inflammatory and antioxidant, as well as the regulation of intestinal flora. In addition, this paper summarizes recent animal experimental and clinical studies on Pueraria mirifica and discusses the therapeutic potential of Pueraria mirifica alone or in combination with other herbal medicines and its safety issues. Although Pueraria mirifica has shown some efficacy in the treatment of obesity, there are still limitations in the relevant studies, and future studies are needed to further validate its clinical ef

关 键 词：葛根 肥胖 脂质代谢 胰岛素敏感性 抗炎抗氧化 肠道菌群 

分 类 号：R285[医药卫生—中药学]