放疗所致的心肌纤维化与microRNA-21的研究进展  

The Progress of Research on Myocardial Fibrosis and microRNA-21 Induced by Radiotherapy

作　　者：杨艳 欧阳伟炜 苏胜发[1,2] 万艳 马筑[1,2] 李青松 王羽 罗大先[1,2] 耿一超 卢冰[1,2] 

机构地区：[1]贵州医科大学附属医院肿瘤科,贵州省肿瘤医院肿瘤科,贵州贵阳 [2]贵州医科大学肿瘤学教研室,贵州贵阳

出　　处：《亚洲肿瘤科病例研究》2018年第4期61-67,共7页Asian Case Reports in Oncology

基　　金：贵州省科技厅课题(黔科合LH字[2014]7135);贵州省教育厅创新群体重大研究项目(黔教合KY[2016]032)。

摘　　要：心脏全部或部分受到一定剂量射线照射,会导致一系列的心功能的损害如心包疾患、心肌纤维化、冠状动脉病变及心脏传导系统损伤等。心肌纤维化是放射性心脏损伤发生发展的重要病理过程。目前多项研究已证实miR-21可加快纤维化进程且在纤维化的组织中异常表达。本文将对心肌纤维化发生机制、病理生理及miR-21与心肌纤维化关系进行阐述,为临床防治放射性心脏损伤提供一定的理论基础。A certain dose of radiation in all or part of the heart can cause pericardial disease, myocardial fi-brosis, coronary artery disease, and heart conduction system damage. Myocardial fibrosis is an important pathological process in the development of radiation-induced heart disease (RIHD). A number of studies have confirmed that miR-21 can accelerate the progression of fibrosis and ab-normal expression in fibrotic tissues. This article will summarize the mechanism of myocardial fi-brosis, path physiology and the relationship between miR-21 and myocardial fibrosis and provide a theoretical basis for the clinical treatment and prevention of radioactive heart damage.

关 键 词：放射性心脏损伤 成纤维细胞 心肌纤维化 MIR-21 

分 类 号：R5[医药卫生—内科学]