网络药理学的应用研究与发展  

Application Research and Development of Network Pharmacology

作　　者：张军军 白育庭 邵开元 胡文祥 

机构地区：[1]湖北科技学院药学院,湖北咸宁 [2]北京神剑天军医学科学院京东祥鹄微波化学联合实验室,北京 [3]中国人民解放军战略支援部队航天系统部,北京

出　　处：《比较化学》2019年第2期11-15,共5页Journal of Comparative Chemistry

摘　　要：网络药理学是基于系统生物学的原理阐释疾病发展的过程,进一步利用网络平衡的整体观来认识药物与机体相互作用的一门学科,具有“多基因、多靶点”的特点,开创了一种多靶点与多种疾病间复杂网状关系的新型模式,在复杂疾病发病机制及治疗靶标的研究方面具有重要的应用价值。本文对网络药理学的相关技术、网络药理学在组合药物及中药学中的应用等方面作了简要综述,为深入研究药理学拓展新的思路。Cyberpharmacology is a discipline that explains the process of disease development based on the principles of systems biology,and further uses the holistic view of network balance to understand the interaction between drugs and organisms.With the characteristics of“multi-gene,multi-target”,it has created a new pattern of complex network relationship between multi-target and multiple diseases,which has important application value in the research of pathogenesis and therapeutic targets of complex diseases.In this paper,the related technology of network pharmacology and the application of network pharmacology in combination drugs and traditional Chinese medicine are reviewed,which will open up new ideas for the further study on pharmacology.

关 键 词：网络药理学 组合药物 中药学 应用 

分 类 号：R2[医药卫生—中医学]