Association of Race and Change in Ankle-Brachial Index: The Atherosclerosis Risk in Communities (ARIC) Cohort  

作　　者：Ericha Franey Donna Kritz-Silverstein Erin Richard John Alcaraz Caroline Nievergelt Richard Shaffer Vibha Bhatnagar Ericha Franey;Donna Kritz-Silverstein;Erin Richard;John Alcaraz;Caroline Nievergelt;Richard Shaffer;Vibha Bhatnagar(Graduate School of Public Health, San Diego State University, San Diego, CA, USA;Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA;Department of Psychiatry, University of California San Diego, La Jolla, CA, USA)

机构地区：[1]Graduate School of Public Health, San Diego State University, San Diego, CA, USA [2]Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA [3]Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

出　　处：《Advances in Aging Research》2020年第5期77-93,共17页老年问题研究（英文）

摘　　要：<strong>Objective</strong>: <span><span><span style="font-family:verdana;">This study evaluates the association of self-reported race with</span><span style="font-family:'Minion Pro Capt','serif';"><span style="font-family:Verdana;"> change in ankle-brachial index (ABI) over time and modification of this association by paraoxonase gene (</span><i><span style="font-family:Verdana;">PON</span></i><span style="font-family:Verdana;">1,</span><i><span style="font-family:Verdana;"> PON</span></i><span style="font-family:Verdana;">2</span><i><span style="font-family:Verdana;"> and PON</span></i><span style="font-family:Verdana;">3) single nucleotide polymorphisms (SNPs). </span></span><b><span style="font-family:verdana;">Methods: </span></b></span></span><span style="font-family:verdana;"><span style="font-family:verdana;"><span style="font-family:verdana;"><span style="font-family:verdana;">This longitudinal study included 11,992 (N</span></span></span></span><span><span><span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">=</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">2952 Black,</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">N</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">=</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:'Minion Pro Capt','serif';"><span style="font-family:Verdana;">9040 White) participants from the Atherosclerosis Risk in Com</span><span style="font-family:verdana;">munities (ARIC) cohort with PON genotyping. Mixed-effects models ex</span><span style="font-family:Verdana;">amined whether race was associated with change in ABI over time after adjustment for known peripheral artery disease (PAD) risk factors.</span></span></span></span></span><span><span><span><span style="font-family:'Minion Pro Capt','serif';"> </span><b><span style="font-fam<strong>Objective</strong>: <span><span><span style="font-family:verdana;">This study evaluates the association of self-reported race with</span><span style="font-family:'Minion Pro Capt','serif';"><span style="font-family:Verdana;"> change in ankle-brachial index (ABI) over time and modification of this association by paraoxonase gene (</span><i><span style="font-family:Verdana;">PON</span></i><span style="font-family:Verdana;">1,</span><i><span style="font-family:Verdana;"> PON</span></i><span style="font-family:Verdana;">2</span><i><span style="font-family:Verdana;"> and PON</span></i><span style="font-family:Verdana;">3) single nucleotide polymorphisms (SNPs). </span></span><b><span style="font-family:verdana;">Methods: </span></b></span></span><span style="font-family:verdana;"><span style="font-family:verdana;"><span style="font-family:verdana;"><span style="font-family:verdana;">This longitudinal study included 11,992 (N</span></span></span></span><span><span><span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">=</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">2952 Black,</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">N</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:verdana;">=</span><span style="font-family:'Minion Pro Capt','serif';"> </span><span style="font-family:'Minion Pro Capt','serif';"><span style="font-family:Verdana;">9040 White) participants from the Atherosclerosis Risk in Com</span><span style="font-family:verdana;">munities (ARIC) cohort with PON genotyping. Mixed-effects models ex</span><span style="font-family:Verdana;">amined whether race was associated with change in ABI over time after adjustment for known peripheral artery disease (PAD) risk factors.</span></span></span></span></span><span><span><span><span style="font-family:'Minion Pro Capt','serif';"> </span><b><span style="font-fam

关 键 词：ankle-brachial index ARIC PARAOXONASE PAD peripheral artery disease SNP single nucleotide polymorphism 

分 类 号：O17[理学—数学]