Factors Associated with Antigen HBs Seroconversion among Blood Donors in Ouagadougou from 2008 to 2017  

作　　者：Abdoul-Guaniyi Sawadogo T. Isidore Traore Salam Sawadogo Kompingnin Nebie Lucien Désiré Dahourou Juste Some Hervé Kpoda Ahmed Kabore Dahourou Honorine Arzouma Paul Yooda Bia Emile Drabo Jean-Etienne Koanda Alain Konseybo Eléonore Kafando Nicolas Meda Léon Blaise Savadogo Abdoul-Guaniyi Sawadogo;T. Isidore Traore;Salam Sawadogo;Kompingnin Nebie;Lucien Désiré Dahourou;Juste Some;Hervé Kpoda;Ahmed Kabore;Dahourou Honorine;Arzouma Paul Yooda;Bia Emile Drabo;Jean-Etienne Koanda;Alain Konseybo;Eléonore Kafando;Nicolas Meda;Léon Blaise Savadogo(Centre National de Transfusion Sanguine (CNTS), Ouagadougou, Burkina Faso;ONG Terre des hommes Lausanne, Ouagadougou, Burkina Faso;Centre MURAZ, Bobo-Dioulasso, Burkina Faso;Université Nazi BONI, Bobo-Dioulasso, Burkina Faso;Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso;Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso;Université Norbert ZONGO, Koudougou, Burkina Faso)

机构地区：[1]Centre National de Transfusion Sanguine (CNTS), Ouagadougou, Burkina Faso [2]ONG Terre des hommes Lausanne, Ouagadougou, Burkina Faso [3]Centre MURAZ, Bobo-Dioulasso, Burkina Faso [4]Université Nazi BONI, Bobo-Dioulasso, Burkina Faso [5]Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso [6]Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso [7]Université Norbert ZONGO, Koudougou, Burkina Faso

出　　处：《Advances in Infectious Diseases》2021年第3期278-289,共12页传染病进展（英文）

摘　　要：<strong>Introduction: </strong>The risk of transmission of pathogens such as hepatitis B virus threatens the safety of transfused patients especially in high endemic areas. The aim of this study was to determine the incidence and factors associated with hepatitis B virus surface antigen (HBsAg) seroconversion in blood donors at the Regional Blood Transfusion Centre of Ouagadougou. <strong>Methods:</strong> A retrospective cohort study of voluntary non-remunerated blood donors (VNRBD), was conducted from 2008 to 2017. Data on HBsAg seroconversion were collected. The Kaplan-Meier method and the Log-Rank test were used to estimate the survival curves. Cox’s regression identified the factors associated with this seroconversion. <strong>Results:</strong> Of 23,494 donors, 559 had HBsAg seroconversion. The number of donor years was 58,637.50 and the HBV incidence rate was 9.53 per 1000 donor years. The median seroconversion time was 75.73 months with extremes of 2.7 months and 107.12 months. The risk of seroconversion was 1.30 times higher among donors aged 21 to 24 years old (p = 0.007) and 2.49 times higher among those over 24 years old (p < 0.0001) than among donors under 21 years old. Female donors were 1.11 times more likely to seroconvert than male donors (p = 0.33). Donor residence was not significantly associated with HBsAg seroconversion (Hazard ratio = 1.12;p = 0.36). The risk of seroconversion decreased significantly with the number of blood donations (Hazard ratio = 0.58;p = 0.006). <strong>Conclusion: </strong>The incidence of HBsAg remains high among blood donors, which could have a negative impact on transfusion safety. The age of the blood donor was significantly associated to AgHBs seroconversion.<strong>Introduction: </strong>The risk of transmission of pathogens such as hepatitis B virus threatens the safety of transfused patients especially in high endemic areas. The aim of this study was to determine the incidence and factors associated with hepatitis B virus surface antigen (HBsAg) seroconversion in blood donors at the Regional Blood Transfusion Centre of Ouagadougou. <strong>Methods:</strong> A retrospective cohort study of voluntary non-remunerated blood donors (VNRBD), was conducted from 2008 to 2017. Data on HBsAg seroconversion were collected. The Kaplan-Meier method and the Log-Rank test were used to estimate the survival curves. Cox’s regression identified the factors associated with this seroconversion. <strong>Results:</strong> Of 23,494 donors, 559 had HBsAg seroconversion. The number of donor years was 58,637.50 and the HBV incidence rate was 9.53 per 1000 donor years. The median seroconversion time was 75.73 months with extremes of 2.7 months and 107.12 months. The risk of seroconversion was 1.30 times higher among donors aged 21 to 24 years old (p = 0.007) and 2.49 times higher among those over 24 years old (p < 0.0001) than among donors under 21 years old. Female donors were 1.11 times more likely to seroconvert than male donors (p = 0.33). Donor residence was not significantly associated with HBsAg seroconversion (Hazard ratio = 1.12;p = 0.36). The risk of seroconversion decreased significantly with the number of blood donations (Hazard ratio = 0.58;p = 0.006). <strong>Conclusion: </strong>The incidence of HBsAg remains high among blood donors, which could have a negative impact on transfusion safety. The age of the blood donor was significantly associated to AgHBs seroconversion.

关 键 词：Time to Onset Viral Hepatitis B Blood Donors SEROCONVERSION 

分 类 号：R51[医药卫生—内科学]