Severe Monkeypox Infection in a Patient with AIDS: An Illustrative Case Report  

作　　者：Dhruv Bakshi Alwyn Rapose Dhinager Nandagopal Sunita Vyas Dhruv Bakshi;Alwyn Rapose;Dhinager Nandagopal;Sunita Vyas(Department of Internal Medicine, St. Vincent Hospital, Worcester, MA, USA;Department of Internal Medicine, St. Vincent Hospital, Massachusetts and Reliant Medical Group, Worcester, MA, USA;Division of Infectious Diseases, St. Vincent Hospital, Massachusetts and Reliant Medical Group, Worcester, MA, USA)

机构地区：[1]Department of Internal Medicine, St. Vincent Hospital, Worcester, MA, USA [2]Department of Internal Medicine, St. Vincent Hospital, Massachusetts and Reliant Medical Group, Worcester, MA, USA [3]Division of Infectious Diseases, St. Vincent Hospital, Massachusetts and Reliant Medical Group, Worcester, MA, USA

出　　处：《Advances in Infectious Diseases》2023年第2期323-332,共10页传染病进展（英文）

摘　　要：The Monkeypox (Mpox) virus (MPXV) is endemic in Africa, and cases outside West and Central Africa were previously considered rare. However, around May 2022, outbreaks of multiple cases were reported worldwide including the USA thus presenting a new public health emergency. We present a case report of MPXV infection in a 49-year-old gay male with AIDS who was admitted for management of severe perianal cellulitis. Three days into hospitalization, he developed pustules over the genitals and scattered lesions over the face, trunk and extremities. PCR testing from a pustule was positive for MPXV. He was initiated on tecovirimat as well as antiretroviral therapy. There was a worsening of his rash over the first three days of therapy, followed by a gradual but complete resolution of all the skin lesions. The perianal and gluteal lesions were the most persistent and took more than two months to resolve. A primary contact source of infection was never identified. The differential diagnoses for cutaneous lesions of MPXV infection are also discussed.The Monkeypox (Mpox) virus (MPXV) is endemic in Africa, and cases outside West and Central Africa were previously considered rare. However, around May 2022, outbreaks of multiple cases were reported worldwide including the USA thus presenting a new public health emergency. We present a case report of MPXV infection in a 49-year-old gay male with AIDS who was admitted for management of severe perianal cellulitis. Three days into hospitalization, he developed pustules over the genitals and scattered lesions over the face, trunk and extremities. PCR testing from a pustule was positive for MPXV. He was initiated on tecovirimat as well as antiretroviral therapy. There was a worsening of his rash over the first three days of therapy, followed by a gradual but complete resolution of all the skin lesions. The perianal and gluteal lesions were the most persistent and took more than two months to resolve. A primary contact source of infection was never identified. The differential diagnoses for cutaneous lesions of MPXV infection are also discussed.

关 键 词：MONKEYPOX Mpox Perianal Cellulitis AIDS Tecovirimat 

分 类 号：R51[医药卫生—内科学]